Development and optimization of a noncontact optical device for online monitoring of jaundice in human subjects

Polley, Nabarun; Saha, Srimoyee; Singh, Soumendra; Adhikari, Aniruddha; Das, Sukhen; Choudhury, Bhaskar Roy; Pal, Samir Kumar

doi:10.1117/1.jbo.20.6.067001

Cited by 24 publications

(13 citation statements)

References 24 publications

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“…Statistical analysis. Analysis of the data was done using descriptive statistical analysis, simple linear regression analysis, and the Bland & Altman method [27][28][29][30][31] . To analyze the accuracy of the device the positive predictive (PPV) and the negative predictive (NPV) values were calculated.…”

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confidence: 99%

Large scale validation of a new non-invasive and non-contact bilirubinometer in neonates with risk factors

Halder

Adhikari

Ghosh

et al. 2020

Sci Rep

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The study was aimed to evaluate the performance of a newly developed non-invasive and noncontact bilirubin measurement device (AJo-neo) as an alternative to the conventional invasive biochemical method of total serum bilirubin (TSB) estimation in preterm and term neonates suffering from hyperbilirubinemia associated with risk factors, and/or undergoing phototherapy. The safety and efficacy of the device were assessed in 1968 neonates with gestational ages ranging from 28 to 41 weeks and suffering from incidences of hyperbilirubinemia. Linear regression analysis showed a good correlation between AJO-Neo and the conventional method of TSB (Pearson's coefficient, r = 0.79). The small bias (0.27 mg/dL) and limits of agreements (− 3.44 to 3.99 mg/dL) were within the range of clinical acceptance. The device was also precise in the measurement of bilirubin levels in all subgroups of the study. The receiver operator curve (ROC), that takes account of both sensitivity and specificity of a device showed high efficacy of the device (area under the curve, AUC = 0.83) in the detection of bilirubin. While monitoring the bilirubin level during phototherapy, the device indicated promising results showing good agreement with TSB. Specificities and sensitivities of the device indicated a much higher accuracy in neonates with associated risk factors for hyperbilirubinemia. Hence, the newly developed device (AJO-Neo) is reliable in measuring bilirubin level in preterm, and term neonates irrespective of gestational or postnatal age, sex, risk factors, feeding behavior or skin color. Neonatal jaundice or Icterus neonatorum affects more than 60% of the term and 80% of preterm newborns in the first week of life 1-3 due to excessive production of bilirubin, and the inability of the newly developed liver to excrete it 4. Although benign at low concentrations, persistently elevated levels of bilirubin can cause severe neurotoxicity termed as kernicterus, which may lead to significant morbidity and mortality 5,6. Thus, proper monitoring of the bilirubin level in newborns is mandatory as per the guideline of American Academy of Pediatrics (AAP) to ensure appropriate management 7. The contemporary method of detection of serum bilirubin

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confidence: 99%

Large scale validation of a new non-invasive and non-contact bilirubinometer in neonates with risk factors

Halder

Adhikari

Ghosh

et al. 2020

Sci Rep

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“…A method for measuring jaundice using non-contact optical devices at the conjunctiva of human subjects was described by Nabarun Polley and his colleagues in 2015 [20]. The light from the source is transmitted through the six excitation fibers of the excitation arm and incident on the subject (conjunctiva).…”

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Design and Development of Electronic Sensor and Monitoring System of Smart Low-cost Phototherapy Light System for Non-Invasive Monitoring and Treatment of Neonatal Jaundice

Cabacungan¹,

Oppus²,

Tangonan³

et al. 2020

Adv. sci. technol. eng. syst. j.

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This paper showcases our previous and continuously improving development at Ateneo Innovation Center (AIC) and partners in designing and further enhancing the existing Lowcost Phototherapy Light System (LPLS) and Improved Low-cost Phototherapy Light System (ILPLS) to the new Smart Low-cost Phototherapy Light System (Smart LPLS) with noninvasive jaundice monitoring for newborns with Neonatal Jaundice (NNJ). Developing this tool will help determine the intensity of yellowish color in infants and can monitor NNJ in a non-invasive way. The system is envisioned to be integrated with Mobile or Near Cloud as part of Smart Nursing Station together with other hospital equipment for monitoring, collection, and management of medical records and services. Its solar-power features for off-grid and remote deployments were also explored. This contribution is an extension of the Intelligent Sensors and Monitoring System for Low-cost Phototherapy Light for Jaundice Treatment that was presented in the International Symposium on Multimedia and Communication Technology (ISMAC) in 2019.

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“…Our innovation is based on the measurement of the spectroscopic signal emanating from the vascular bed of the bulbar conjunctiva. 21 As the conjunctiva in all humans is transparent and has white sclera as background, 22 the accuracy and sensitivity of the proposed device are independent of the skin color of the subjects. The easy access to the conjunctiva and its high vascular visibility ensures that the proposed device has high accuracy and sensitivity.…”

Section: Development and Validation Of A Noncontact Spectroscopic Devmentioning

confidence: 99%

Development and validation of a noncontact spectroscopic device for hemoglobin estimation at point-of-care

et al. 2017

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Anemia severely and adversely affects human health and socioeconomic development. Measuring hemoglobin with the minimal involvement of human and financial resources has always been challenging. We describe a translational spectroscopic technique for noncontact hemoglobin measurement at low-resource point-of-care settings in human subjects, independent of their skin color, age, and sex, by measuring the optical spectrum of the blood flowing in the vascular bed of the bulbar conjunctiva. We developed software on the LabVIEW platform for automatic data acquisition and interpretation by nonexperts. The device is calibrated by comparing the differential absorbance of light of wavelength 576 and 600 nm with the clinical hemoglobin level of the subject. Our proposed method is consistent with the results obtained using the current gold standard, the automated hematology analyzer. The proposed noncontact optical device for hemoglobin estimation is highly efficient, inexpensive, feasible, and extremely useful in low-resource point-of-care settings. The device output correlates with the different degrees of anemia with absolute and trending accuracy similar to those of widely used invasive methods. Moreover, the device can instantaneously transmit the generated report to a medical expert through e-mail, text messaging, or mobile apps.

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Development and optimization of a noncontact optical device for online monitoring of jaundice in human subjects

Cited by 24 publications

References 24 publications

Large scale validation of a new non-invasive and non-contact bilirubinometer in neonates with risk factors

Large scale validation of a new non-invasive and non-contact bilirubinometer in neonates with risk factors

Design and Development of Electronic Sensor and Monitoring System of Smart Low-cost Phototherapy Light System for Non-Invasive Monitoring and Treatment of Neonatal Jaundice

Development and validation of a noncontact spectroscopic device for hemoglobin estimation at point-of-care

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