Development and Optimization of Astragalin-Loaded Polymeric Nanoparticles Using Central Composite Factorial Design

Abstract

Objective: The objective of the present study was to develop and optimize Astragalin-loaded polymeric nanoparticles (AST-NPs) using a central composite factorial design (CCD). Methods: AST-NPs were prepared by the dialysis method. CCD was employed to study the influence of formulation factors, polymer concentration, aqueous organic phase ratio, and process parameter stirring time on dependent physicochemical characteristics, particle size, zeta potential, and percentage entrapment efficiency (%EE) of the drugs. The optimized formulation was evaluated for in vitro release studies and subjected to stability studies. Results: Polymer concentration and process parameters were optimized to produce nanoparticles with desired parameters. The prepared NPs were characterized by Fourier transmission infrared (FT-IR), differential scanning calorimetry (DSC), drug loading, entrapment efficiency, particle size, zeta potential, and in vitro studies. FT-IR and DSC studies indicated that there was no interaction between the drug and polymer. The optimized NPs exhibits stability. Optimized NPs exhibited spherical and porous surfaces with a mean PS of 118 nm, the zeta potential of-25 mV, and %EE of 89%. Conclusion: Astragalin-loaded nanoparticles prepared with optimized formulation composition and process parameters.

Central Composite Face-Centered Design-Based Optimisation, Development and Characterisation of Favipiravir-Loaded Plga Nanoparticles

“…1b and the curve in the contour plot fig. 1c also assure the same [38]. Hence, the drug entrapment efficiency will increase with an increase in all three factors [39].…”

“…The results are presented in table 6. The low magnitude of relative error, less than±2%, confers the robustness and predictability of software in preparing the stable Favipiravir-loaded PLGA nanoparticles [38,44]. This result indicated that there was no interaction between favipiravir and polymers during the preparation of favipiravirloaded PLGA nanoparticles [22,24].…”

The Promises of the Potential Uses of Polymer Biomaterials in Biomedical Applications and Their Challenges

“…Synthetic polymers are the most versatile materials, and their use in biomedical applications includes contact lenses, pharmaceutical vehicles, dental materials, substrates for tissue engineering, and others [43]. Research should focus on developing biodegradable and/or bioabsorbable synthetic polymers that can decompose as tissue regeneration progresses, as is the case with polyacrylates, polysiloxanes, polyamides, polycarbonates, polyesters, polyurethanes, polystyrenes, synthetic polypeptides, polyalkenes, and polyols [44,45].…”

“…It has been endorsed in orthopedics as an adhesive for bones, cranial prostheses, and bone repairs [45,46]. Other PMMA applications also include its use as a vehicle for delivering genetic material, replacing viral vehicles [44].…”