Development and optimization of fast dissolving oro-dispersible films of granisetron HCl using Box–Behnken statistical design

Chaudhary, Hema; Gauri, Samita; Rathee, Permender; Kumar, Vikash

doi:10.1016/j.bfopcu.2013.05.002

Cited by 74 publications

(71 citation statements)

References 14 publications

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“…Fast-dissolving drug delivery systems (FD-DDSs) were first developed in the late 1970s and 43 rapidly gained interest in the pharmaceutical industry (Chaudhary et al, 2013;Hoffmann et 44 al., 2011). These delivery systems either dissolve or disintegrate in the mouth very rapidly, 45 without requiring any water to aid in swallowing.…”

mentioning

confidence: 99%

Fast dissolving paracetamol/caffeine nanofibers prepared by electrospinning

Illangakoon

Gill

Shearman

et al. 2014

International Journal of Pharmaceutics

151

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mentioning

confidence: 99%

Fast dissolving paracetamol/caffeine nanofibers prepared by electrospinning

Illangakoon

Gill

Shearman

et al. 2014

International Journal of Pharmaceutics

151

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“…The polymeric solutions were then poured on the mold, allowed to dry and stored in aluminum foil. 15 The different formulations were prepared incorporating polymer (2.5-3.0% w/v), plasticizer (1.5-2.5% w/v), and water using 3 2 central composite design and optimized formulation was generated using statistical screening. The eleven runs of the experiment were evaluated for the percentage folding endurance (Y 1 ), T 90% (Y 2 , time required to release 90% of drug), disintegration time (Y 3 ) are listed in Table 3.…”

Section: Preparation Of Orodispersible Films (Odf)mentioning

confidence: 99%

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2014

IJPSR

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ABSTRACT:The aim of present research work to develop and optimize orodispersible film of baclofen to improve bioavailability and patient compliance. Orodispersible films of baclofen were prepared by solvent casting method using HPMC E5 LV as a film forming polymer and propylene glycol as a plasticizer, crospovidone as a superdisintegrant and sucralose was added as a sweetener. The physical mixture of drug and polymer characterized by FT-IR showed no incompatibility. A 3 2 central composite design was applied using two independent variables such as X 1 (Polymer) and X 2 (Propylene glycol) and folding endurance (Y 1 ), T 90% (Y 2 ), In-vitro Disintegration time (Y 3 ).The prepared films were evaluated for weight, thickness, folding endurance, disintegration time, in vitro drug release, drug content and their mechanical properties such as tensile strength and % elongation. From the result obtained optimized formulation was prepared with 2.58% w/v HPMC E5 LV and 2.02 % w/v of propylene glycol showed folding endurance of 68.59, disintegration time 53.4 seconds,T 90% of 9.12 minutes. A stability study result reveals that there was no significant change after one month.

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“…The polymer used for the preparation of film had good film forming property with non-toxic, nonirritant, good wetting properties [10]. This polymer played important role in imparting necessary mechanical properties to the film.…”

Section: Patientmentioning

confidence: 99%

“…The animal studies were performed as per the international CPCSEA guidelines. Porcine oral mucosa was soaked previously for 24 h in pH 6.8 phosphate buffer [10,13]. This oral mucosa was stretched around one end of the diffusion cell.…”

Section: Ex Vivo Permeation Studiesmentioning

confidence: 99%

“…Oral fast disintegrating films are easy to administer and provide better patient compliance in the elderly, pediatric, mentally retarded, nauseated and uncooperative patients [10]. Thus, the aim of the present study was to develop oral fastdisintegrating films of LVX for the management of hypothyroidism in pediatrics for improved patient compliance.…”

Section: Introductionmentioning

confidence: 99%

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