Development and Physical Characterization of a Periodontal Bioadhesive Gel of Gatifloxacin

Kassab, Hanan J.; Thomas, Lena Murad; Jabir, Saba Abdulhadi

doi:10.22159/ijap.2017v9i3.7056

Cited by 15 publications

(12 citation statements)

References 12 publications

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“…The prepared formulations were colourless, viscous with no any aggregations and grittiness [14]. The physiological range of the nasal mucosa temperature lies between 32 and 35°C [15].…”

Section: Discussionmentioning

confidence: 95%

Development of Metoclopramide Hydrochloride in Situ Gel: Nasal Delivery and Pharmacokinetics in New Zealand Rabbits

Galgatte

Chaudhari

2019

Asian J Pharm Clin Res

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Objective: Systemic bioavailability of metoclopramide hydrochloride (MCH) is 32–80% by oral route. The study was targeted to develop in situ gel of MCH for nasal delivery and to study its pharmacokinetics in healthy rabbits. Pre-systemic metabolism can be overcome. Methods: Poloxamer 407 (P407) aqueous solutions were prepared by cold method. In 32 factorial design, independent variables were Carbopol 934P and polyethylene glycol 6000 (PEG 6000), and dependent responses were gelation temperature, mucoadhesive strength, and drug release. A Pharmacokinetic study was carried out in New Zealand rabbits. The optimized in situ gel (1 mg/ml) was compared with marketed Reglan® (2 mg/2 ml) injection. Area under the curve (AUC), Cmax, and Tmax were estimated. Results: F2 was an optimized formulation. The study showed that P407 solutions formed a gel at nasal temperature 34°C having mucoadhesive strength 806.12±3.45 dyne/cm2. MCH release was found to be 93.74±1.31% within 6 h. Histopathological examination of formulation F2 exhibited safety to the nasal mucosa. The pH of formulations was 5.1±0.1 to 5.6±0.1 in the range of pH of nasal cavity. Plasma samples were analyzed by liquid chromatography/mass spectroscopy (LC/MS). The area under curve AUC0-4 for in situ gel by nasal route was 2716±4.617 ng/h/ml and for marketed solution by intravenous route was 2874±1.0816 ng/h/ml. These were comparable. Nasal bioavailability was found 94.50% from in situ gel. Duration of action was longer, and steady-state concentration was found for in situ gel. Conclusion: In situ gel was capable to release MCH in systemic circulation. In vivo study in rabbits has proved the improved bioavailability of MCH administered nasally. The optimized gel preparation was found to be promising for improved bioavailability.

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“…The prepared formulations were colourless, viscous with no any aggregations and grittiness [14]. The physiological range of the nasal mucosa temperature lies between 32 and 35°C [15].…”

Section: Discussionmentioning

confidence: 95%

Development of Metoclopramide Hydrochloride in Situ Gel: Nasal Delivery and Pharmacokinetics in New Zealand Rabbits

Galgatte

Chaudhari

2019

Asian J Pharm Clin Res

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“…In the study conducted by Kassab et al, in 2017, a biphasic release profile was reported for gatifloxacin from periodontal bioadhesive gel. The authors attributed the initial burst effect to the drug which is present freely in the gel matrix [48].…”

Section: In Vitro Drug Releasementioning

confidence: 99%

Plga Nanoparticles Loaded Mucoadhesive and Thermosensitive Hydrogel as a Potential Platform for the Treatment of Oral Mucositis

El-Feky¹,

Zayed

2019

Int J App Pharm

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Objective: The objective of this study was to design an effective topical treatment for oral mucositis.Methods: Poly-(DL-lactide-co-glycolide) (PLGA) nanoparticles (NPs) and Poloxamer407 (PLX)/Hydroxy propyl methyl cellulose (HPMC) hydrogel matrix (HG) were used as combined carriers for benzydamine HCL (BNZ). BNZ loaded PLGA nanoparticles were assessed for their particle size, PDI, zeta potential and entrapment efficiency. Scanning electron microscopy, thermosensitivity study, mucoadhesion study, in vitro release and in vivo investigation were used to characterize the combined BZN loaded PLGA NPs HG.Results: Negatively charged NPs with an average diameter of 139±4.92 nm were incorporated into PLX/HPMC HG bases. The gelation temperature of BZN-PLGA-NPs-HGs ranged between 31°C and 36.5°C. When diluted with saliva simulated fluid, BZN-PLGA-NPs-HGs preserved their gelation properties. Mucoadhesion was found lower for formulations prepared with PLX without HPMC. An increase in the concentrations of PLX from 10 to 30% resulted in an increase in adhesion. Both PLGA-NPs and PLGA-NPs-HG provided a biphasic drug release profile while BZN-HG provided monophasic zero order release pattern. The in vivo study showed that animal groups treated with BZN-HG and BZN-PLGA-NPs-HG showed a significantly higher reduction percentage in ulcer surface area compared to those treated with BZN-PLGA-NPs. BZN-PLGA-NPs-HG group needed 10 d of treatment to complete healing versus 16 d, 14 d and 12 d for the complete healing of groups with no treatment, treated with BZN-PLGA-NPs and treated with BZN-HG, respectively.Conclusion: BZN-PLGA-NPs-HG could represent a promising mean for the effective treatment of oral mucositis induced by cancer therapy.

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“…The dissolution medium phosphate buffer pH 7.4 was maintained at 37±5℃. The suitable volume of the sample was withdrawn at predetermined time periods; the same was replenished with fresh buffer and samples were assayed spectrophotometrically [8].…”

Section: In Vitro Release Studiesmentioning

confidence: 99%

Formulation and Evaluation of Aceclofenac Proniosome Loaded Orabase for Management of Dental Pain

et al. 2018

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Objective: The main motive is to develop proniosomes loaded orabase for enhanced permeation and prolonged release of aceclofenac for oro dental conditions.Methods: Various aceclofenac (ACL) proniosomal gels were formulated employing various surfactants, span 60 was superior and significant for loading into orabase. The formulations were scrutinized for entrapment efficiency, optical microscopy, in vitro diffusion and release studies, mucoadhesive strength, ex-vivo permeation studies and drug-excipient interactions were determined by FTIR spectroscopy.Results: Considering best entrapment efficiency with span 60 (97.60±1.85) and optimum vesicle shape, along with prolonged drug permeation (45% for 24 h) the formulation F(ACL)1 was selected and optimized for loading into orabase. The F(ACL)1 loaded orabase exhibited significant prolonged release over 14 h, and permeation profiles exhibited nearly two-fold increased flux in comparison with control. Good mucoadhesive strength was observed for proniosomal orabase 6370 dynes/cm2. No evidence of incompatibility amongst formulation components from FTIR studies. SEM images revealed the particle size range from 136 µm to 236 µm for proniosomal orabase.Conclusion: Orabase can be an effective carrier for proniosomes with enhanced permeation and prolonged release for oro-dental conditions.

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Development and Physical Characterization of a Periodontal Bioadhesive Gel of Gatifloxacin

Cited by 15 publications

References 12 publications

Development of Metoclopramide Hydrochloride in Situ Gel: Nasal Delivery and Pharmacokinetics in New Zealand Rabbits

Development of Metoclopramide Hydrochloride in Situ Gel: Nasal Delivery and Pharmacokinetics in New Zealand Rabbits

Plga Nanoparticles Loaded Mucoadhesive and Thermosensitive Hydrogel as a Potential Platform for the Treatment of Oral Mucositis

Formulation and Evaluation of Aceclofenac Proniosome Loaded Orabase for Management of Dental Pain

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