Development and physico-mechanical characterization of carrageenan and poloxamer-based lyophilized matrix as a potential buccal drug delivery system

Oral transmucosal drug delivery for pediatric use

“…Similar to oral films are oral lyophilized wafers, which are thin, flat disk-like dosage form that are currently undergoing investigation for drug absorption through the oral mucosal [109][110][111][112][113][114]. Lyophilized wafers have also been used in wound healing drug delivery [115,116].…”

A focus on mucoadhesive polymers and their application in buccal dosage forms

“…They have a higher drug loading capacity compared to the thin and continuous solvent cast films, due to their higher surface area and porous structure [151] and have been used in different drug delivery systems including fast dissolving wafers and wound healing dressings [154e156]. Lyophilized wafers by freeze-drying gels containing 2% w/w kcarrageenan 911, 4% w/w P407 and 4.4% w/w PEG 600, with optimum physicalemechanical properties, have been prepared by Kianfar F. et al, as a potential buccal delivery system of soluble and insoluble drugs [157,158]. The presence of k-carrageenan, due to its ability to form hydrogen bonds and dative bonds between the sulfate group and the NH 2 groups present in mucin on the buccal mucosa, resulted in strong mucoadhesion forces.…”

Cellulose Buccoadhesive Film Bearing Glimepiride: Physicomechanical Characterization and Biophysics of Buccoadhesion

“…Sample was blended with potassium bromide (1:100) and analyzed by FTIR spectrophotometer in the range of 4,000-400 cm −1 . FTIR spectra were obtained and studied for interaction between drug and polymers (7,8).…”