“…On the other hand, several issues are still unresolved, such as wear and adverse tissue responses, which heighten the risk of implants loosening [1][2][3][4]. During the last ten years, particular attention was paid to metal on metal (MoM) coupling for arthroprosthesis, because of lower volumetric wear compared to metal on polyethylene (MoP) coupling, as well as higher durability than ceramic on ceramic (CoC) coupling [5][6][7][8]. Mechanical and chemical degradation of joint devices (MoP or MoM) leads to polyethylene and metal debris formation, which means release of metal particulate and ions [9][10][11][12].…”