Development and quality assessment of glutathione tripeptide loaded niosome containing carbopol emulgels as nanocosmeceutical formulations

Inal, Ozge; Amasya, Gülin; Bayındır, Zerrin Sezgin; Yüksel, Nilüfer

doi:10.1016/j.ijbiomac.2023.124651

Cited by 8 publications

(3 citation statements)

References 44 publications

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“…It is important to note that the equations (15), and (16) for the flow velocities are only applicable when H p H/2, otherwise both the u and u p are zero in the channel and the fluid is completely plugged without any motion. The volume flow rate in a deformable channel is given by…”

Section: D Planar Modelmentioning

confidence: 99%

“…HerschelBulkley fluids, which exhibit these characteristics, are commonly encountered in various applications, including but not limited to food processing [4][5][6], the oil and gas industry [7], biomedical applications [8,9] such as the flow through tubes, pipes, and hoses, and in polymer processing industries like extrusion and injection molding [10,11]. Additionally, they find use in pharmaceutical formulations and processing [12][13][14][15] as well as in waste management [16,17]. Understanding how these yield stress materials flow within flexible channels is crucial for optimizing processing conditions, preventing blockages, and ensuring consistent product quality.…”

Section: Introductionmentioning

confidence: 99%

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Yield–stress shear thinning and shear thickening fluid flows in deformable channels

Garg,

Prasad

2024

Phys. Scr.

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Yield stress shear thinning/thickening fluids flow through flexible channels, tubes are widespread in the natural world with many technological applications. In this paper, analytical formulae for the velocity profiles and flow rate are derived using the Herschel--Bulkley rheological model in both rigid and deformable shallow channels, employing the lubrication approximation. To account for deformable walls, the approach outlined by \citet{gervais2006flow} and \citet{christov2018flow} is utilized, applying small displacement structural mechanics and perturbation theory, respectively. The newly derived formulae also enable the analysis of flow dynamics in Newtonian fluids, power-law fluids, and Bingham fluids as their limiting cases, all of which have been previously described in the literature and also serves as the validation cases. It is observed that deformability increases the effective channel height and the flow rate within the channel. Multiple scaling relationships for the flow rate are identified under different applied pressure regimes and deformability parameters. Additionally, it is noted that increasing the yield stress results in decreased velocity in both the plug flow and non-plug flow regions. Higher yield stress also corresponds to an increase in the yield surface height and the solid plug within the central region, leading to a reduction in the flow rate. Furthermore, the shear thinning/thickening index is found to have no impact on plug height, although an increase in this index causes a reduction in the flow rate due to the corresponding increase in shear thickening of the material.

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Section: D Planar Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Yield–stress shear thinning and shear thickening fluid flows in deformable channels

Garg,

Prasad

2024

Phys. Scr.

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“…Herschel-Bulkley fluids flow in the deformable channels are common with several applications. Examples include in food processing [1,2,3], in the oil and gas industry [7], in the biomedical applications [8,9] (flow through tubes, pipes, and hoses) for conveying, distribution, and transport in polymer processing industries, such as extrusion and injection molding [60,61], in the pharmaceutical formulations and processing [62,63,64], in the waste management [65,66,67]. To optimize the processing conditions, preventing blockages, and ensuring consistent product quality, the understanding of the flow behavior of yield stress materials in the flexible channels play a vital role.…”

Section: Introductionmentioning

confidence: 99%

Wall-slip effects on the Yield-stress fluid flows in the rigid and deformable channel

Garg,

Prasad

2023

Preprint

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Yield stress fluids flow through deformable conduits and are prevalent in nature and have numerous technological applications [1-11]. In this paper, we focus on investigating the impact of many factors such as the deformability of the channel-wall, yield stress, shear-thinning, and shear-thickening index in the presence of slip and compared it with flow dynamics with no-slips as predicted by Garg and Prasad [12]. Using lubrication theory, we have derived a model for the velocity profiles and flow rate using the Herschel-Bulkley rheological model in rigid and deformable shallow channels with slip-walls. To model deformable walls, we have utilized small displacement structural mechanics and perturbation theory presented by Gervais et al. [13] and Christov et al. [14], respectively. Our newly developed model encompasses the flow characteristics of Newtonian fluids, power-law fluids, and Bingham fluids, both with and without wall-slip, as observed in previous literature [13-16]. We find that the deformability increases the same effective channel height with and without wall-slip but the flow rate is increased more when slips are present within the channel. We find many scalings for the flow rate under different regimes of applied pressure and the deformability parameter. A threshold inlet pressure is required for the onset of yield-stress fluid flow in the channels unlike in the case of the Newtonian or power-law fluids. Garg and Prasad [12] finds that below this threshold, the flow is choked in the channels with plug height the same as the channel height: we find the same observations in the presence of slips. Although in case of deformable channels an early onset of flow with the pressure is found in comparison to the rigid channel. We observe the back flow due to deformability in the channel when the yield surface is between $H_o/2 < H_p < (H_o+\delta)/2$, where $H_o$ and $H_p$ represents the initial height of the channel without deformability and the yield surface’s height, respectively. $\delta$ is the increase in channel's height due to deformability. Beyond choked flow, the plug height decreases for both the rigid and the deformable channels with the pressure. We also observe that for any given applied pressure and yield stress, the $(H_p)_{\text{deformable}} < (H_p)_{\text{rigid}}$. This suggests that deformable walls decrease the plug region in comparison to the rigid channel. We also find that the wall-slip has no effect on the plug region and the onset of flow. In the presences of wall-slip, we also find that increasing the yield stress leads to a decrease in the velocity in the plug flow as well as in the non-plug flow regions. Increasing yield stress also leads to increasing the yield surface height and the solid plug in the central region due to which there is decrease in the flow rate similar to as found by Garg and Prasad [12]. Further, we also find that the shear thinning/thickening index does not affect the plug height, although as the index increases, the flow rate starts to decrease due to the corresponding increase in shear thickening of the material.

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Box-Behnken design based optimization of polyvinylpyrrolidone stabilized valproic acid nanoemulsion and evaluation of its anticancer potential

Hegde,

Juvale,

Puri

et al. 2024

Colloid Polym Sci

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Development and quality assessment of glutathione tripeptide loaded niosome containing carbopol emulgels as nanocosmeceutical formulations

Cited by 8 publications

References 44 publications

Yield–stress shear thinning and shear thickening fluid flows in deformable channels

Yield–stress shear thinning and shear thickening fluid flows in deformable channels

Wall-slip effects on the Yield-stress fluid flows in the rigid and deformable channel

Box-Behnken design based optimization of polyvinylpyrrolidone stabilized valproic acid nanoemulsion and evaluation of its anticancer potential

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