Development and release mechanism of diltiazem HCl prolonged release matrix tablets

Boyapally, Harikrishna; Nukala, Ravi Kumar; Douroumis, Dionysios

doi:10.1080/10717540802586220

Cited by 18 publications

(9 citation statements)

References 38 publications

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“…Matrix systems are comprised of hydrophobic (nonswellable) polymers, or hydrophilic (swellable/hydrogel) polymers . In some cases, both hydrophobic and hydrophilic polymers are utilized . Hydrophilic polymers swell upon hydration and dissolve, hence the drug is released slowly across the hyrogel formed surrounding the dosage form.…”

Section: Polymeric Matrix Tablets For Modified Drug Releasementioning

confidence: 99%

Applications of Polymers as Pharmaceutical Excipients in Solid Oral Dosage Forms

2016

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Over the last few decades, polymers have been extensively used as pharmaceutical excipients in drug delivery systems. Pharmaceutical polymers evolved from being simply used as gelatin shells comprising capsule to offering great formulation advantages including enabling controlled/slow release and specific targeting of drugs to the site(s) of action (the "magic bullets" concept), hence hold a significant clinical promise. Oral administration of solid dosage forms (e.g., tablets and capsules) is the most common and convenient route of drug administration. When formulating challenging molecules into solid oral dosage forms, polymeric pharmaceutical excipients permit masking undesired physicochemical properties of drugs and consequently, altering their pharmacokinetic profiles to improve the therapeutic effect. As a result, the number of synthetic and natural polymers available commercially as pharmaceutical excipients has increased dramatically, offering potential solutions to various difficulties. For instance, the different polymers may allow increased solubility, swellability, viscosity, biodegradability, advanced coatings, pH dependency, mucodhesion, and inhibition of crystallization. The aim of this article is to provide a wide angle prospect of the different uses of pharmaceutical polymers in solid oral dosage forms. The various types of polymeric excipients are presented, and their distinctive role in oral drug delivery is emphasized. The comprehensive know-how provided in this article may allow scientists to use these polymeric excipients rationally, to fully exploit their different features and potential influence on drug delivery, with the overall aim of making better drug products.

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Section: Polymeric Matrix Tablets For Modified Drug Releasementioning

confidence: 99%

Applications of Polymers as Pharmaceutical Excipients in Solid Oral Dosage Forms

2016

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“…Isoniazid encapsulated in Eudragit RL-PO showed a faster release compared to RS-PO, which is due to the high water permeability of the RL-PO polymer. 15 The higher burst release observed for isoniazid could also be due to the presence of the drug molecules on the surface of the microparticles. This could be correlated to the high encapsulation efficiency of isoniazid in both polymers, in which the drug might be deposited on the outer surface of the microparticles instead of being encapsulated within.…”

Section: In-vitro Drug Release Studymentioning

confidence: 99%

Eudragit as the Material for the Production of Rifampicin and Isoniazid Microparticles

Hwai¹,

Gazzali²

2019

JPS

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Rifampicin and isoniazid are two of the first-line drugs used to treat tuberculosis (TB). Rifampicin is sensitive to light, heat and moisture, and is also known to have poor solubility which affects the absorption of the drug in the gastrointestinal tract. This study was conducted to investigate the effects of different types of Eudragit® in the formulation of microparticles of rifampicin and isoniazid. Two types of Eudragit were used which are Eudragit RL-PO and Eudragit RS-PO. The particle size of rifampicin microparticles for Eudragit RL-PO and Eudragit RS-PO were recorded at 44 µm and 64 µm, respectively. Isoniazid microparticles were found to have volume mean diameters of 63 µm and 54 µm for formulations incorporated with Eudragit RL-PO and Eudragit RS-PO, respectively. Eudragit RL-PO formulated rifampicin microparticles encapsulated 80.8% and 23.3% for those formulated with Eudragit RS-PO. Isoniazid microparticles recorded an encapsulation efficiency of 98.7% and 61.9% in formulations using Eudragit RL-PO and Eudragit RS-PO correspondingly. The formulations retained some of the functional groups, but changes were also observed. Scanning electron microscope (SEM) shows consistently spherical and porous microparticles with rough surfaces. Dissolution studies indicate that isoniazid was released by Quasi-Fickian mechanism while rifampicin was released by non-Fickian mechanism.

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“…22 Many studies have reported that the Higuchi model suitably describes porous matrix systems. 23,24 The Higuchi model is based on Fickian diffusion, 25 which has always been used for the diffusion behavior of moisture sorption. 9,26 Therefore, the moisture sorption behavior of the hot-melt coating pellets could be explained as water vapor diffusion via the porous matrix system.…”

Section: Hygroscopicity Of Pelletsmentioning

confidence: 99%

Combined application of extrusion-spheronization and hot-melt coating technologies for improving moisture-proofing of herbal extracts

Chen

Shi

Liu

et al. 2010

Journal of Pharmaceutical Sciences

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Development and release mechanism of diltiazem HCl prolonged release matrix tablets

Cited by 18 publications

References 38 publications

Applications of Polymers as Pharmaceutical Excipients in Solid Oral Dosage Forms

Applications of Polymers as Pharmaceutical Excipients in Solid Oral Dosage Forms

Eudragit as the Material for the Production of Rifampicin and Isoniazid Microparticles

Combined application of extrusion-spheronization and hot-melt coating technologies for improving moisture-proofing of herbal extracts

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