Development and systematic characterization of GelMA/alginate/PEGDMA/xanthan gum hydrogel bioink system for extrusion bioprinting

“…308 XG and its blends have received much attention as a potential biomaterials ink for creating complex 3D biomimetic scaffolds for specific tissue regenerative applications. 233,309,310 Yang et al developed an extrusion 3D-printed dressing approach, wherein GelMA/xanthan gum-based biomaterials ink was used to fabricate 3D-printed dressing in severe wound sites for controlled wound healing. 311 The antibacterial wound dressing ink was fabricated to reduce bacterial infection by incorporating N-halamine/TiO 2 into GelMA (15%)/XG (1−3%) hydrogel.…”

Section: Ma Et Al Synthesized N-(2-aminoethyl)-4-(4-(hydroxymethyl)-mentioning

confidence: 99%

“…Xanthan gum (XG), a viscosity modifier, is an FDA-approved water-soluble, biocompatible, and biodegradable high-molecular-weight heteropolysaccharide secreted by the microorganism Xanthomonas campestris (NRRL B-1459) during fermentation. − Moreover, XG showed higher thermal stability due to the ordered helical structure than many other water-soluble polysaccharides . XG and its blends have received much attention as a potential biomaterials ink for creating complex 3D biomimetic scaffolds for specific tissue regenerative applications. ,, Yang et al developed an extrusion 3D-printed dressing approach, wherein GelMA/xanthan gum-based biomaterials ink was used to fabricate 3D-printed dressing in severe wound sites for controlled wound healing . The antibacterial wound dressing ink was fabricated to reduce bacterial infection by incorporating N -halamine/TiO 2 into GelMA (15%)/XG (1–3%) hydrogel.…”

Section: Modulating Scaffold Properties Through Gelma Ink Modificationsmentioning

confidence: 99%

Gelatin Methacryloyl (GelMA)-Based Biomaterial Inks: Process Science for 3D/4D Printing and Current Status

Das,

Jegadeesan,

Basu

2024

Biomacromolecules

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Tissue engineering for injured tissue replacement and regeneration has been a subject of investigation over the last 30 years, and there has been considerable interest in using additive manufacturing to achieve these goals. Despite such efforts, many key questions remain unanswered, particularly in the area of biomaterial selection for these applications as well as quantitative understanding of the process science. The strategic utilization of biological macromolecules provides a versatile approach to meet diverse requirements in 3D printing, such as printability, buildability, and biocompatibility. These molecules play a pivotal role in both physical and chemical cross-linking processes throughout the biofabrication, contributing significantly to the overall success of the 3D printing process. Among the several bioprintable materials, gelatin methacryloyl (GelMA) has been widely utilized for diverse tissue engineering applications, with some degree of success. In this context, this review will discuss the key bioengineering approaches to identify the gelation and cross-linking strategies that are appropriate to control the rheology, printability, and buildability of biomaterial inks. This review will focus on the GelMA as the structural (scaffold) biomaterial for different tissues and as a potential carrier vehicle for the transport of living cells as well as their maintenance and viability in the physiological system. Recognizing the importance of printability toward shape fidelity and biophysical properties, a major focus in this review has been to discuss the qualitative and quantitative impact of the key factors, including microrheological, viscoelastic, gelation, shear thinning properties of biomaterial inks, and printing parameters, in particular, reference to 3D extrusion printing of GelMA-based biomaterial inks. Specifically, we emphasize the different possibilities to regulate mechanical, swelling, biodegradation, and cellular functionalities of GelMA-based bio(material) inks, by hybridization techniques, including different synthetic and natural biopolymers, inorganic nanofillers, and microcarriers. At the close, the potential possibility of the integration of experimental data sets and artificial intelligence/machine learning approaches is emphasized to predict the printability, shape fidelity, or biophysical properties of GelMA bio(material) inks for clinically relevant tissues.

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“…This formulation offered excellent printability at room temperature, tunable mechanical properties, and cytocompatibility, yet it may have limited shear-thinning properties. 108 a dual cross-linked network based on sodium alginate graft copolymer with P(NIPAM-co-NtBAM) side chains (Saravanou et al). This formulation underwent a two-stage gelation process, providing gentle 3D printing capabilities and supporting cell growth.…”

Section: Nanomaterials-based Hybrid Bioinksmentioning

confidence: 99%

Nanomaterials-Based Hybrid Bioink Platforms in Advancing 3D Bioprinting Technologies for Regenerative Medicine

Chandra,

Reis,

Kundu

et al. 2024

ACS Biomater. Sci. Eng.

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3D bioprinting is recognized as the ultimate additive biomanufacturing technology in tissue engineering and regeneration, augmented with intelligent bioinks and bioprinters to construct tissues or organs, thereby eliminating the stipulation for artificial organs. For 3D bioprinting of soft tissues, such as kidneys, hearts, and other human body parts, formulations of bioink with enhanced bioinspired rheological and mechanical properties were essential. Nanomaterials-based hybrid bioinks have the potential to overcome the above-mentioned problem and require much attention among researchers. Natural and synthetic nanomaterials such as carbon nanotubes, graphene oxides, titanium oxides, nanosilicates, nanoclay, nanocellulose, etc. and their blended have been used in various 3D bioprinters as bioinks and benefitted enhanced bioprintability, biocompatibility, and biodegradability. A limited number of articles were published, and the above-mentioned requirement pushed us to write this review. We reviewed, explored, and discussed the nanomaterials and nanocomposite-based hybrid bioinks for the 3D bioprinting technology, 3D bioprinters properties, natural, synthetic, and nanomaterial-based hybrid bioinks, including applications with challenges, limitations, ethical considerations, potential solution for future perspective, and technological advancement of efficient and cost-effective 3D bioprinting methods in tissue regeneration and healthcare.

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Development and systematic characterization of GelMA/alginate/PEGDMA/xanthan gum hydrogel bioink system for extrusion bioprinting

Cited by 25 publications

References 71 publications

Multifunctional hydrogel dressing based on fish gelatin/oxidized hyaluronate for promoting diabetic wound healing

Multifunctional hydrogel dressing based on fish gelatin/oxidized hyaluronate for promoting diabetic wound healing

Gelatin Methacryloyl (GelMA)-Based Biomaterial Inks: Process Science for 3D/4D Printing and Current Status

Nanomaterials-Based Hybrid Bioink Platforms in Advancing 3D Bioprinting Technologies for Regenerative Medicine

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