Development and validation a novel preoperative comprehensive prognostic score based on inflammatory and nutritional score, coagulation indicator and tumor marker in esophageal squamous cell carcinoma

Abstract

We herein propose a novel integrative score based on inflammatory and nutritional score, coagulation indicator and tumor marker, named comprehensive prognostic score (CPS), to predict postoperative survival in resectable esophageal squamous cell carcinoma (ESCC). We also aimed to establish and validate a nomogram based on CPS and other clinical features for individual survival prediction. A total of 490 resectable ESCC patients were randomly divided into either a training or validation cohort at a ratio of 7:3 for retrospective analysis. The CPS, based on squamous cell carcinoma antigen (SCCA), C-reactive protein to albumin ratio (CAR), neutrophil to lymphocyte ratio (NLR), and fibrinogen (FIB), was divided into two models to verify its prognostic value. The predictive model of CPS-based nomogram was established and validated in two cohorts. Patients with CPS low group in model 1 had better 5-year cancer-specific survival (CSS) than those in CPS high group (50.7% vs. 17.8%, P<0.001). For model 2, the 5-year CSS for CPS 0, 1 and 2 were 75.0%, 38.9% and 13.3%, respectively (P<0.001). CPS was confirmed as an independent prognostic score in both models. The CPS-based nomogram can accurately and effectively predict survival in resected ESCC. The CPS is a novel, simple, and effective predictor in resectable ESCC. Moreover, CPS has a potential independent prognostic value in predicting postoperative survival, which can accurately and effectively predict individual survival in resectable ESCC.

Preoperative BChE serves as prognostic marker in patients with resectable AEG after neoadjuvant chemotherapy

“…In that study, an association of decreased serum BChE levels with impaired DFS and OS and an indirect correlation to advanced tumor stage was observed in patients with cervical cancer. Not only an association of advanced tumor stage or enlarged tumor mass and chronic in ammation has been described in previous studies [32], but also an association of ongoing systemic in ammation and decreased serum BChE [22,33]. Therefore, it indicates that decreased serum BChE levels may illustrate an ongoing chronic in ammatory reaction as a result of underlying and advanced malignancy.…”

Prognostic Value of Inflammation-Immunity-Nutrition Score and Inflammatory Burden Index for Hepatocellular Carcinoma Patients After Hepatectomy

“…These indicators include C-reactive protein/albumin ratio (CAR), platelet-lymphocyte ratio (PLR), systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), prognostic nutritional index (PNI), prognostic index (PI), Glasgow prognostic score (GPS), and modified Glasgow prognostic score (mGPS). [7][8][9][10][11] The inflammation-immunity-nutrition score (IINS), a combination of C-reactive protein (CRP), lymphocyte (LYM) count and serum albumin (ALB) level, 12 has shown promising prognostic performance in colorectal cancer, 12 endometrial cancer, 13 and HCC treated with therapy targeting programmed cell death protein 1. 14 Similarly, the inflammatory burden index (IBI) is also a potential inflammatory biomarker that can be used to predict prognosis in patients with colorectal cancer, esophageal cancer, gastric cancer, 15 pancreatic cancer 16 or bladder cancer.…”