Development and Validation of a New LC–MS/MS Analytical Method for Direct-Acting Antivirals and Its Application in End-Stage Renal Disease Patients

Farouk, Faten; Wahba, Dina; Mogawer, Sherif; Elkholy, Shaimaa; Elmeligui, Ahmed M.; Abdelghani, Reham; Ibahim, Salwa

doi:10.1007/s13318-019-00584-6

Cited by 5 publications

(1 citation statement)

References 38 publications

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“…[ 126 ]; [ 136 ]; [ 137 ]; [ 152 ]; [ 154 ]; [ 155 ]; [ 156 ]; [ 157 ]; [ 158 ]; [ 159 ]; [ 160 ]; [ 161 ]; [ 162 ]; [ 163 ]; [ 164 ]; [ 165 ]; [ 166 ]; [ 167 ]; [ 168 ].…”

Section: Uncited Referencesunclassified

Detection and quantification of Covid-19 antiviral drugs in biological fluids and tissues

Acquavia

Foti

Pascale

et al. 2021

Talanta

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Since coronavirus disease 2019 (COVID-19) started as a fast-spreading pandemic, causing a huge number of deaths worldwide, several therapeutic options have been tested to counteract or reduce the clinical symptoms of patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, no specific drugs for COVID-19 but many antiviral agents have been authorised by several national agencies. Most of them are under investigation in both preclinical and clinical trials; however, pharmacokinetic and metabolism studies are needed to identify the most suitable dose to achieve the desired effect on SARS-CoV-2. Therefore, the efforts of the scientific community have focused on the screening of therapies able to counteract the most severe effects of the infection, as well as on the search of sensitive and selective analytical methods for drug detection in biological matrices, both fluids and tissues. In the last decade, many analytical methods have been proposed for the detection and quantification of antiviral compounds currently being tested for COVID-19 treatment. In this review, a critical discussion on the overall analytical procedure is provided, i.e (a) sample pre-treatment and extraction methods such as protein precipitation (PP), solid-phase extraction (SPE), liquid–liquid extraction (LLE), ultrasound-assisted extraction (UAE) and QuEChERS (quick, easy, cheap, effective, rugged and safe), (b) detection and quantification methods such as potentiometry, spectrofluorimetry and mass spectrometry (MS) as well as (c) methods including a preliminary separation step, such as high performance liquid chromatography (HPLC) and capillary electrophoresis (CE) coupled to UV-Vis or MS detection. Further current trends, advantages and disadvantages and prospects of these methods have been discussed, to help the analytical advances in reducing the harm caused by the SARS-CoV-2 virus.

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“…[ 126 ]; [ 136 ]; [ 137 ]; [ 152 ]; [ 154 ]; [ 155 ]; [ 156 ]; [ 157 ]; [ 158 ]; [ 159 ]; [ 160 ]; [ 161 ]; [ 162 ]; [ 163 ]; [ 164 ]; [ 165 ]; [ 166 ]; [ 167 ]; [ 168 ].…”

Section: Uncited Referencesunclassified

Detection and quantification of Covid-19 antiviral drugs in biological fluids and tissues

Acquavia

Foti

Pascale

et al. 2021

Talanta

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Tandem mass spectrometry of small-molecule antiviral drugs: 2. hepatitis-related antivirals

Niessen¹

2020

International Journal of Mass Spectrometry

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Analytical Methods for the Determination of Major Drugs Used for the Treatment of COVID-19. A Review

Ruos

Baldo

Daniele

2022

Critical Reviews in Analytical Chemistry

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Development and Validation of a New LC–MS/MS Analytical Method for Direct-Acting Antivirals and Its Application in End-Stage Renal Disease Patients

Cited by 5 publications

References 38 publications

Detection and quantification of Covid-19 antiviral drugs in biological fluids and tissues

Detection and quantification of Covid-19 antiviral drugs in biological fluids and tissues

Tandem mass spectrometry of small-molecule antiviral drugs: 2. hepatitis-related antivirals

Analytical Methods for the Determination of Major Drugs Used for the Treatment of COVID-19. A Review

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