Objective
The coronavirus disease 2019
(COVID-19) pandemic has had a serious impact on health all over the
world. Cancer patient, whose immunity is often compromised, faces a huge
challenge. Currently, some COVID-19 vaccines are being developed and
applied on general population; however, whether cancer patients should
take COVID-19 vaccine remains unknown. Our study aimed to explore the
knowledge, attitude, acceptance, and predictors of intention to receive
the COVID-19 vaccine among cancer patients in Eastern
China.
Methods
A cross-sectional study was conducted
in Eastern China from June 17th to September 3rd, 2021. Patients were
selected using a convenience sampling method. A self-report questionnaire
was developed to assess knowledge about the COVID-19 vaccine, attitude
towards the vaccine and acceptance of the vaccine; following a review of
similar studies previously published in the scientific literature,
multivariate logistic regression analysis was used to determine the
predictors associated with COVID-19 vaccine acceptance.
Results
A total of 2158 cancer patients were
enrolled in this study. The rate of vaccine hesitancy was 24.05%
(519/2158); further, among the participants of vaccine acceptance, 767
had taken COVID-19 vaccine (35.54%), and 872 were willing to get
vaccinated (40.01%). A total of 24 variables including demographic
characteristics, clinical status of cancer, impact of COVID-19 pandemic
on study participants, patients’ knowledge about the COVID-19 vaccine,
and attitude towards the vaccine, had significant differences between the
“vaccine hesitancy” population and “vaccine acceptance” population.
Multivariate logistic regression analysis indicated that parameters
including alcohol consumption (odds ratio [OR] = 1.849; 95% confidence
interval [CI]: 1.375–2.488;
P
-reference
[
P
-Ref] < 0.001
vs
non-drinkers), income impacted by COVID-19 pandemic (OR = 1.930, 2.037
and 2.688 for mild, moderate, and severe impact, respectively; all
P
-Ref < 0.01
vs
no
impact), knowledge of how the vaccine was developed (OR = 1.616; 95% CI:
1.126–2.318;
P
-Ref = 0.009
vs
unknown), believing in the safety of the
vaccine (OR = 1.502; 95% CI: 1.024–2.203;
P
-Ref =
0.038
vs
denying the safety of vaccine),
willingness to pay for the vaccine (OR = 3.042; 95% CI: 2.376–3.894;
P
-Ref < 0.001
vs
unwilling), and willingness to recommend families and friends to get
vaccinated (OR = 2.744; 95% CI: 1.759–4.280;
P
-Ref
< 0.001
vs
do not recommend) were contributors
to vaccine acceptance. While such as being retired (OR = 0.586; 95% CI:
0.438–0.784;
P
-Ref < 0.001
vs...