2015
DOI: 10.3329/bpj.v16i2.22295
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Development and Validation of a Simple RP-HPLC Method for Determination of Naproxen in Pharmaceutical Dosage Forms

Abstract: A simple, sensitive and precise reversed phase high performance liquid chromatographic (RP-HPLC) method has been developed for the estimation of naproxen in pharmaceutical dosage forms. The method was developed using the mobile phase comprising of dibasic sodium phosphate buffer (Na 2 HPO 4 ) at pH 7.80 (adjusted by sodium hydroxide) and acetonitrile in the ratio of 70:30 (v/v) over C-18 column (250 x 4.6 mm, 5µm, Phenomenex Inc.) at ambient temperature. The flow rate was at 0.7 ml/min and the column washing w… Show more

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Cited by 20 publications
(6 citation statements)
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“…Some of the reported methods for determination of NPS includes titrimetric , potentiometric (Lenik et al, 2002;Uysal et al,2004),spectrophotometric (Maheshwari et al, 2009 andYola et al, 2011;Kulsum et al,2011;Dharmalingam et al, 2013), mass spectrometric (Pracz et al, 2012), electrophoretic (Macia et al,2008),GC (Singh et al, 1991;), HPLC (Tashtoush et al, 2003;Mehta et al, 2012;Haque et al, 2012;Tanjin et al, 2013) and LC-MS (Elsinghorst et al, 2011) methods. The literature survey indicates there is only a single stability-indicating UPLC method for determination of NPS (Venkatarao et al, 2012).…”
Section: Introductionmentioning
confidence: 99%
“…Some of the reported methods for determination of NPS includes titrimetric , potentiometric (Lenik et al, 2002;Uysal et al,2004),spectrophotometric (Maheshwari et al, 2009 andYola et al, 2011;Kulsum et al,2011;Dharmalingam et al, 2013), mass spectrometric (Pracz et al, 2012), electrophoretic (Macia et al,2008),GC (Singh et al, 1991;), HPLC (Tashtoush et al, 2003;Mehta et al, 2012;Haque et al, 2012;Tanjin et al, 2013) and LC-MS (Elsinghorst et al, 2011) methods. The literature survey indicates there is only a single stability-indicating UPLC method for determination of NPS (Venkatarao et al, 2012).…”
Section: Introductionmentioning
confidence: 99%
“…It works by inhibiting both the COX-1 and COX-2 enzymes. Literature survey reveals that there are some UV [10][11][12][13][14] and HPLC [15][16][17][18], HPTLC [19], UPLC [17], LC/MS [20,21], Capillary electrophoresis [22] methods for the estimation of Naproxen in pharmaceutical formulations, and in rat serum by HPTLC [23]. The official method for independent determination of Naproxen is by acid-base titration and that for Esomeprazole magnesium is by HPLC [24].…”
mentioning
confidence: 99%
“…They act by inhibiting the prostaglandin synthesis thereby producing several side effects such as ulceration and gastrointestinal bleeding [3][4][5]. Although many high-performance liquid chromatographic methods have been developed for the estimation of naproxen sodium alone [2,5] or in combination for the simultaneous determination of naproxen with other drugs in different matrices. These methods involved derivatization and post-column photochemical reactions, mostly used buffer solution as mobile phase due to which the mobile phase becomes complex.…”
Section: Introductionmentioning
confidence: 99%
“…These methods involved derivatization and post-column photochemical reactions, mostly used buffer solution as mobile phase due to which the mobile phase becomes complex. But there is always a need of a meaningful cost-effective method for estimation of naproxen sodium because the present methods do not provide the sensitivity [1,2,5]. The aim of the present study was to develop a simple and effective RP-HPLC method for quantification of naproxen in pharmaceutical preparations [5][6][7][8][9] as well as in spiked human plasma and animal plasma (rabbits) [7,10,11] in a very short time and to validate that method according to ICH and FDA guidelines (Food and drug administration 2012; United states Pharmacopoeia 2007; International Conference on Harmonization (ICH) 2005;).…”
Section: Introductionmentioning
confidence: 99%
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