2023
DOI: 10.21203/rs.3.rs-3120720/v1
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Development and validation of a hepatocellular carcinoma classifier based on macrophage-related gene set for rapid evaluation of patient response types and prognosis

Abstract: Tumor-associated macrophages (TAMs) participate in and shape the tumor microenvironment of hepatocellular carcinoma (HCC), which is closely related to the formation of tumor heterogeneity. The aim of this study is to distinguish different subtypes of patients according to the activity level of macrophage functional gene set in HCC. We collected 1203 tissue samples from TCGA, ICGC and GEO databases. Using macrophage-associated gene set (MRRGS) from GSEA database, the score of MRRGS was calculated based on gene … Show more

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