Development and Validation of a New Near-Infrared Sensor to Measure Polyethylene Glycol (PEG) Concentration in Water

Abstract

A near-infrared absorption based laser sensor has been designed and validated for the real-time measurement of polyethylene glycol (PEG) concentration. The wavelength was selected after the determination of the absorption spectrum of deionised water and PEG solutions using a Varian Cary 6000i spectrophotometer, in order to limit the influence of PEG molecular mass on the absorption measurement. With this new sensor, the water is treated as the attenuating species and the addition of PEG in water reduces the absorbance of the medium. The concept was validated using three different PEG types (PEG 6000, 20,000, and 35,000) and it was found that the results follow Beer Lambert’s law. The influence of temperature was assessed by testing the PEG 20,000 at four different temperatures that could be encountered in a laboratory environment. The data show a slight temperature influence (increase of absorbance by 8% when the temperature rises from about 20° to about 29°). Following the validation phase conducted ex situ, a prototype of an immersible sensor was built and calibrated for in situ measurements.

Fiber-Optic Chemical Sensors and Biosensors (2015–2019)

“…A near-IR absorption based laser sensor was designed to determine the concentration of poly(ethylene glycol) (PEG) in water. 289 By selecting a suitable wavelength (1392 nm), a linear correlation is found between the concentration of PEG and absorbance which obeyed the Beer−Lambert law. The correlation is independent of the PEG molecular weight.…”

Photoelectric detection of crop fungi resistance based on microfluidic

“…Optical detection of particulate media containing is based on the different absorption of light (attenuation of light energy) at different wavelengths of the medium, i.e. the different transmittances of different light waves through different media [21]. The nature of each medium (particle size, concentration etc.)…”

Exploring Novel Sensor Design Ideas through Concentration-Induced Conformational Changes in PEG Single Chains

“…Therefore, the widespread application of PEG as a sensor material and its unique conformational adjustability confer on it a pivotal role in the sensor domain. Its biocompatibility positions it as an ideal material for biosensors, while its conformational adjustability propels innovation in designing novel sensors [27][28][29][30]. While it is possible to induce conformational changes in PEG chains under specific conditions, a more in-depth investigation into the specific mechanisms governing conformational control is warranted.…”