Development and validation of a risk-prediction nomogram for patients with ureteral calculi associated with urosepsis: A retrospective analysis

Hu, Ming; Zhong, Xintai; Cui, Xuejiang; Xu, Xun; Zhanying, Zhang; Guan, Lixian; Feng, Qing; Huang, Yiheng; Hu, Weilie

doi:10.1371/journal.pone.0201515

Cited by 27 publications

(29 citation statements)

References 40 publications

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“…Urolith induced obstructive urosepsis occurs predominantly in female patients, 7 which also holds true in our study in that the male to female ratio was 1:3.5. The reason is considered to be related to the anatomical characteristics of female lower urinary tract, the higher incidence of female lower urinary tract infection, and the refractory infection of drug-resistant bacteria.…”

Section: Discussionsupporting

confidence: 86%

Risk Factors for Progression to Severe Sepsis or Septic Shock in Patients with Urolith Induced Obstructive Urosepsis

Cao¹,

Wang²,

Wang³

et al. 2020

Preprint

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Introduction: To analyze the risk factors for the progression to severe sepsis,or septic shock,in pre-hospital patients with urolith Induced obstructive urosepsis, so as to facilitate the early identification of high-risk patients.Materials and Methods: Datas were retrospectively reviewed from 160 patients of urolith induced obstructive urosepsis between December 2013 and December 2019. There were 49 patients complicated by severe sepsis (severe sepsis group), 12 patients with septic shock (septic shock group), and 99 patients without progression to severe sepsis or septic shock (sepsis group). The data covered age, gender, BMI , time interval from ED to admission, WBC count, NLR, HGB, etc. Datas were analyzed by univariate analyses and multivariate logistic regression analysis.Results: Univariate analysis showed that the differences of age, the time interval from ED to admission, history of diabetes mellitus, history of CKI, NLR, HGB, platelet count, TBil, SCr, ALB, PT, APTT, INR, PCT, and positive rate of pathogens in blood culture were statistically significant (P < 0.05). Multivariate logistic regression analysis showed that age, SCr, and history of CKI were independent risk factors for progression to severe sepsis, or septic shock (P < 0.05).Conclusions: Aged ≥ 65 years, SCr ≥ 248 mol/L, and history of CKI were independent risk factors for progression to severe sepsis, or septic shock, in patients with urolith induced obstructive urosepsis. The key to prevent urosepsis from progression is to improve our understanding of disease dynamics, control the risk factors, and intervene the pre-hospital patients with multidisciplinary modalities as early as possible.

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Section: Discussionsupporting

confidence: 86%

Risk Factors for Progression to Severe Sepsis or Septic Shock in Patients with Urolith Induced Obstructive Urosepsis

Cao¹,

Wang²,

Wang³

et al. 2020

Preprint

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“…To our knowledge, this study is the first to assess factors associated with injured CPN and establish a prediction model to predict the prognosis of injured CPN by using a nomogram. It is generally believed that the model with AUC of 0.50-0.75 is acceptable, and AUC > 0.75 indicates that the discrimination of model is prominent [35]. AUC of our prediction model is 0.904, so this nomogram can be used to predict the prognosis of injured CPN well.…”

Section: Discussionmentioning

confidence: 78%

Analysis of Prognostic Risk Factors for Operative Common Peroneal Nerve: A Nest Case-Control Study

Liu¹,

Yushan²,

Liu³

et al. 2020

Preprint

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Background Common peroneal nerve (CPN) injury is one of the most common nerve injuries in the lower extremities and the motor functional recovery of injured common peroneal nerve (CPN) was often unsatisfactory, the mechanism of which is still controversial. The purpose of this retrospective study was to determine the factors associated with the neural recovery of injured CPN in patients undergoing surgical exploration of CPN.Methods This is a retrospective cohort study of all patients who underwent neural exploration for injured CPN from 2009 to 2019. A total of 387 patients with postoperative follow-up more than 12 months were included in the final analysis. We used univariate logistics regression analyses to assess which explanatory variables are associated with recovery of neurological function. We used multivariable logistic regression analysis to determine variables incorporated into clinical prediction model, developed a nomogram by the selected variables, and then assessed discrimination of the model by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve.Results There were 67 patients divided into case group and 320 patients divided into control group. In multivariate logistic regression analysis, we found that city area (OR = 3.35), labor occupation (OR = 4.39), diabetes (OR = 11.68), cardiovascular disease (OR = 51.35), knee joint dislocation (OR = 14.91), proximal fibula fracture (OR = 3.32), tibial plateau fracture (OR = 9.21), vascular injury (OR = 5.37) and hip arthroplasty (OR = 75.96) injury increased the risk of poor motor functional recovery of injured CPN, while high preoperative muscle strength (OR = 0.18) and postoperative knee joint immobilization (OR = 0.11) decreased this risk of injured CPN. AUC of the nomogram was 0.904 and 95% CI was 0.863–0.946.Conclusions City area, labor occupation, diabetes, cardiovascular disease, knee joint dislocation, proximal fibula fracture, tibial plateau fracture, vascular injury and hip arthroplasty injury are independent risk factors of motor functional recovery of injured CPN, while high preoperative muscle strength and postoperative knee joint immobilization are protective factor of motor functional recovery of injured CPN. The prediction nomogram can be used to predict the prognosis of injured CPN.

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“…To our knowledge, this study is the first to assess factors associated with injured CPN and establish a prediction model to predict the prognosis of injured CPN by using a nomogram. It is generally believed that the model with AUC of 0.50–0.75 is acceptable, and AUC > 0.75 indicates that the discrimination of model is prominent [ 42 ]. AUC of our prediction model is 0.904, so this nomogram can be used to predict the prognosis of injured CPN well.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors in patients who underwent surgery for common peroneal nerve injury: a nest case–control study

et al. 2021

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Background Common peroneal nerve (CPN) injury is one of the most common nerve injuries in the lower extremities and the motor functional recovery of injured common peroneal nerve (CPN) was often unsatisfactory, the mechanism of which is still controversial. The purpose of this retrospective study was to determine the prognostic factors in patients who underwent surgery for CPN injury and provide a tool for clinicians to assess the patients’ prognosis. Methods This is a retrospective cohort study of all patients who underwent neural exploration for injured CPN from 2009 to 2019. A total of 387 patients with postoperative follow-up more than 12 months were included in the final analysis. We used univariate logistics regression analyses to explore explanatory variables which were associated with recovery of neurological function. By applying multivariable logistic regression analysis, we determined variables incorporated into clinical prediction model, developed a nomogram by the selected variables, and then assessed discrimination of the model by the area under the curve (AUC) of the receiver operating characteristic (ROC) curve. Results The case group included 67 patients and the control group 320 patients. Multivariate logistic regression analysis showed that area (urban vs rural, OR = 3.35), occupation(“blue trouser” worker vs “white-trouser” worker, OR = 4.39), diabetes (OR = 11.68), cardiovascular disease (OR = 51.35), knee joint dislocation (OR = 14.91), proximal fibula fracture (OR = 3.32), tibial plateau fracture (OR = 9.21), vascular injury (OR = 5.37) and hip arthroplasty (OR = 75.96) injury increased the risk of poor motor functional recovery of injured CPN, while high preoperative muscle strength (OR = 0.18) and postoperative knee joint immobilization (OR = 0.11) decreased this risk of injured CPN. AUC of the nomogram was 0.904 and 95% CI was 0.863–0.946. Conclusions Area, occupation, diabetes, cardiovascular disease, knee joint dislocation, proximal fibula fracture, tibial plateau fracture, vascular injury and hip arthroplasty injury are independent risk factors of motor functional recovery of injured CPN, while high preoperative muscle strength and postoperative knee joint immobilization are protective factors of motor functional recovery of injured CPN. The prediction nomogram can provide a tool for clinicians to assess the prognosis of injured CPN.

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Development and validation of a risk-prediction nomogram for patients with ureteral calculi associated with urosepsis: A retrospective analysis

Cited by 27 publications

References 40 publications

Risk Factors for Progression to Severe Sepsis or Septic Shock in Patients with Urolith Induced Obstructive Urosepsis

Risk Factors for Progression to Severe Sepsis or Septic Shock in Patients with Urolith Induced Obstructive Urosepsis

Analysis of Prognostic Risk Factors for Operative Common Peroneal Nerve: A Nest Case-Control Study

Prognostic factors in patients who underwent surgery for common peroneal nerve injury: a nest case–control study

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