Development and validation of a prediction model of catheter-related thrombosis in patients with cancer undergoing chemotherapy based on ultrasonography results and clinical information

Abstract

Central venous catheters can be used conveniently to deliver medications and improve comfort in patients with cancer. However, they can cause major complications. The current study aimed to develop and validate an individualized nomogram for early prediction of the risk of catheter-related thrombosis (CRT) in patients with cancer receiving chemotherapy. In total, 647 patients were included in the analysis. They were randomly assigned to the training (n = 431) and validation (n = 216) cohorts. A nomogram for predicting the risk of CRT in the training cohort was developed based on logistic regression analysis results. The accuracy and discriminatory ability of the model were determined using area under the receiver operating characteristic curve (AUROC) values and calibration plots. Multivariate logistic regression analysis showed that body mass index, risk of cancer-related thrombosis, d-dimer level, and blood flow velocity were independent risk factors of CRT. The calibration plot showed an acceptable agreement between the predicted and actual probabilities of CRT. The AUROC values of the nomogram were 0.757 (95% confidence interval: 0.717–0.809) and 0.761 (95% confidence interval: 0.701–0.821) for the training and validation cohorts, respectively. Our model presents a novel, user-friendly tool for predicting the risk of CRT in patients with cancer receiving chemotherapy. Moreover, it can contribute to clinical decision-making.

Evaluation of risk factors for thrombosis after ultrasound-guided internal jugular vein catheterization in patients with lymphoma

“…In 1984, Legler and Nugent 6 were the rst to propose the use of ultrasound for locating the central catheterization of the internal jugular vein. Real-time ultrasound-guided internal jugular vein catheterization allows for visualization of the alignment between arteries and veins, signi cantly reducing the risk of inadvertent catheter insertion into the internal carotid artery 7,8 . As a result, ultrasound-guided internal jugular vein catheterization has become the preferred puncture method for clinicians.…”

Study on PTFE Superhydrophobic Coating Modified by IC@dMSNs and its Enhanced Antibacterial Effect

“…However, due to the high cost of use and the need for further evaluation of effectiveness, it is currently not widely used (15,16). In terms of anticoagulation, anticoagulants or low-dose heparin are still used throughout the body to seal the catheter, while anticoagulant catheters are still in the research stage (17). In recent years, many researchers have begun to study superhydrophobic materials in human body implantation materials, but due to unsatisfactory preparation methods and material properties, mature products have not been produced(18).…”