Development and validation of a high-throughput headspace solid-phase microextraction gas chromatography-mass spectrometry methodology for target and suspect determination of honey volatiles

Gialouris, Panagiotis-Loukas P.; Koulis, Georgios A.; Nastou, Eleni S.; Dasenaki, Marilena E.; Maragou, Niki C.; Thomaidis, Nikolaos S.

doi:10.1016/j.heliyon.2023.e21311

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Book1

Article1

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Sampling techniques for the determination of the volatile fraction of honey

Musci,

Cirlini,

Caligiani

2024

Reference Module in Chemistry, Molecular Sciences and Chemical Engineering

View full text Add to dashboard Cite

Sampling techniques for the determination of the volatile fraction of honey

Musci,

Cirlini,

Caligiani

2024

Reference Module in Chemistry, Molecular Sciences and Chemical Engineering

View full text Add to dashboard Cite

Volatile Organic Compounds in Honey: Tandem Mass Spectrometry as Tool to Quantitate Priority VOCs

Tzanetou,

Vousaxaki,

Machera

et al. 2024

Separations

View full text Add to dashboard Cite

A headspace gas chromatographic tandem mass spectrometric (HS-GC-MS/MS) method was developed and fully validated, aiming for the simultaneous determination of 25 volatile organic compounds (VOCs, some of them previously unreported in honey bee studies) in 52 selected honey samples from Greece. The HS conditions were optimized, and method validation criteria were extensively investigated. The existence impact of the matrix effect was assessed, and matrix-matched calibration curves were developed for quantification purposes. The limits of quantification of the 25 analytes ranged from 0.2 ng g−1 to 0.6 ng g−1. Isoprene was the most commonly detected VOC, followed by octane and styrene. Other detected VOCs include benzene, n-hexane, trimethylbenzenes, xylenes, toluene, and p-dichlorobenzene. Concentrations fluctuated from 0.5 ng g−1 for isoprene and toluene, as well as 1,2,4-trimethylbenzene, to 22.6 ng g−1 for isoprene. Despite VOCs not being at the forefront of honey’s potential contamination, their prevalence in honey can provide significant data for human health risk assessment, considering their undisputable widespread consumption and the documented potential toxicity of VOCs in humans. In this sense, risk assessment for adults and children, as depicted in the hazard quotient and index and carcinogenic risk determination, did not disclose any potential threat after consumption of the investigated honey samples.

show abstract

Development and validation of a high-throughput headspace solid-phase microextraction gas chromatography-mass spectrometry methodology for target and suspect determination of honey volatiles

Cited by 2 publications

References 37 publications

Sampling techniques for the determination of the volatile fraction of honey

Sampling techniques for the determination of the volatile fraction of honey

Volatile Organic Compounds in Honey: Tandem Mass Spectrometry as Tool to Quantitate Priority VOCs

Contact Info

Product

Resources

About