Development and validation of a new simplified diagnostic scoring system for pediatric autoimmune hepatitis

Arcos-Machancoses, José Vicente; Busoms, Cristina Molera; Tatis, Ecaterina Julio; Bovo, María Victoria; Bernabeu, Jesús Quintero; Goñi, Javier; Martínez, Vanessa Crujeiras; Carpi, Javier Martín de

doi:10.1016/j.dld.2019.02.018

Cited by 5 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The pediatric age group may have certain limitations in diagnosis, as over half of children have no autoantibodies and do not show hypergammaglobulinemia, which can lead to false-negative results [48][49][50]. Thus, the simplified scoring system has a much lower sensitivity in this age group [49].…”

Section: Pediatric Autoimmune Hepatitismentioning

confidence: 99%

“…Thus, the simplified scoring system has a much lower sensitivity in this age group [49]. Machancoses et al [50] proposed a simplified diagnostic scoring system after studying 100 cases of pediatric autoimmune hepatitis, which included five criteria: autoantibodies (0-2 points), hypergammaglobulinemia, exclusion of viral hepatitis, exclusion of Wilson's disease (1 point each), and interface hepatitis or multilobular collapse on liver histology (3 points). In addition, a normal cholangiogram is mandatory.…”

Section: Pediatric Autoimmune Hepatitismentioning

confidence: 99%

See 1 more Smart Citation

Autoimmune Hepatitis: From Evolution to Current Status—A Pathologist’s Perspective

Sakhuja,

Goyal

2024

Diagnostics

View full text Add to dashboard Cite

Autoimmune hepatitis (AIH) is a chronic, relapsing and remitting, immune-mediated liver disease that progresses to cirrhosis if left untreated. A significant number of patients may present with acute hepatitis or acute liver failure, which are often misdiagnosed as toxic liver injury. AIH shows a preponderance in young women but may be seen in children and the elderly. Diagnosis requires the integration of clinical, biochemical, and serologic parameters, along with supportive liver histology and exclusion of other causes of liver disease. Liver biopsy is a prerequisite for diagnosis of AIH, to assess severity and stage of disease, exclude other entities, and recognize any concurrent morbidities. No single biomarker or histologic feature is pathognomonic for AIH. The diagnostic and histologic criteria have undergone several modifications since the original scoring system was proposed by the International Autoimmune Hepatitis Group (IAIHG) in 1993. Recently, the IAIHG has proposed consensus recommendations for histologic criteria, relevant for both acute and chronic AIH. This review article will describe the evolving diagnostic criteria for AIH, with their limitations and utility, and with an emphasis on the role of liver histology in the diagnosis and management of AIH.

show abstract

Section: Pediatric Autoimmune Hepatitismentioning

confidence: 99%

Section: Pediatric Autoimmune Hepatitismentioning

confidence: 99%

Autoimmune Hepatitis: From Evolution to Current Status—A Pathologist’s Perspective

Sakhuja,

Goyal

2024

Diagnostics

View full text Add to dashboard Cite

show abstract

Spectrum of Pediatric Autoimmune Hepatitis in a Cohort of Pakistani Children

Khan,

Ali,

Farooq

et al. 2024

Global Pediatric Health

View full text Add to dashboard Cite

Background. Autoimmune hepatitis (AIH) is increasingly seen in children worldwide and it is more severe in children compared to adults. This study highlights the biochemical and clinical aspect, treatment given and outcome of the disease including pediatric liver transplantation. Study. Retrospective review (2012-2022) was done in Shifa International Hospital, Islamabad. Patients under 18 years diagnosed with AIH were included. Data related to age, gender, clinical features, laboratory investigations including liver function test, liver biopsy findings and imaging modalities were included. Results. Fifteen patients were included 7 (47%) were males and 8 (53%) females. AIH type 1 was the most common type seen in 7 (46%), AIH type 2 in 5 (33%) and seronegative in 3 (20%). Jaundice was the most common symptom. Liver biopsy showed findings characteristic of AIH. Liver transplant performed in 3 patients. Conclusion. The study highlights the varied clinical presentation of AIH in Pakistani children.

show abstract

Asymptomatic autoimmune hepatitis type 1 with normal IgG level and IgA deficiency – case report

Mititelu¹,

Grama²,

Spîrchez³

et al. 2021

Pediatru.ro

View full text Add to dashboard Cite

Development and validation of a new simplified diagnostic scoring system for pediatric autoimmune hepatitis

Cited by 5 publications

References 33 publications

Autoimmune Hepatitis: From Evolution to Current Status—A Pathologist’s Perspective

Autoimmune Hepatitis: From Evolution to Current Status—A Pathologist’s Perspective

Spectrum of Pediatric Autoimmune Hepatitis in a Cohort of Pakistani Children

Asymptomatic autoimmune hepatitis type 1 with normal IgG level and IgA deficiency – case report

Contact Info

Product

Resources

About