Development and Validation of a Risk Score for Predicting Hospitalization in Children With Influenza Virus Infection

Bender, Jeffrey M.; Ampofo, Kwabena Krow; Gesteland, Per H.; Stoddard, Gregory J.; Nelson, Douglas S.; Byington, Carrie L.; Pavia, Andrew T.; Srivastava, Rajendu

doi:10.1097/pec.0b013e3181a792a9

Cited by 27 publications

(21 citation statements)

References 36 publications

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“…Our findings are also consistent with CDC alerts on emergency warning signs of pandemic (H1N1) 2009 influenza ( 8 ) and a recent report by Echevarría-Zuno et al ( 9 ) from Mexico in which dyspnea, tachypnea, and cyanosis were prognostic factors for admission and death. Although the presence of any 1 underlying high-risk medical condition has been previously described as a risk factor for complication with seasonal influenza including hospitalization ( 10 ), a higher number of high-risk medical conditions is a stronger predictor of hospitalization (median number 2 vs. 0; p = 0.01).…”

Section: Discussionmentioning

confidence: 95%

“…Although excellent clinical prediction rules for hospitalization of patients with community-acquired pneumonia are available (e.g., CURB-65 or pneumonia severity index), few data exist for influenza admissions ( 10 , 11 ). We propose a simple clinical guide for hospitalization of patients with pandemic (H1N1) 2009 infection by using results of our multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Predicting Need for Hospitalization of Patients with Pandemic (H1N1) 2009, Chicago, Illinois, USA

Vasoo

Singh²,

Trenholme³

2010

Emerg. Infect. Dis.

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In the absence of established guidelines for hospitalization of patients with pandemic (H1N1) 2009, we studied emergency department patients to identify clinical parameters that predict need for hospitalization. Independent predictors of hospitalization include multiple high-risk medical conditions, dyspnea, and hypoxia. These findings are easily applicable, with a 79% positive predictive value for hospitalization.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Predicting Need for Hospitalization of Patients with Pandemic (H1N1) 2009, Chicago, Illinois, USA

Vasoo

Singh²,

Trenholme³

2010

Emerg. Infect. Dis.

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“…A few small cohort studies reported the proportion of children presenting at the emergency room in France21 and in USA,22 and the proportion of health care visits in the USA,6,23 caused by influenza B and A(H3N2). Influenza B-associated hospitalization rates in our study during 2011–2012 were more than twice the rates associated with A(H3N2).…”

Section: Discussionmentioning

confidence: 99%

The substantial hospitalization burden of influenza in central China: surveillance for severe, acute respiratory infection, and influenza viruses, 2010–2012

Huang

Yang³

et al. 2013

Influenza Resp Viruses

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BackgroundPublished data on influenza in severe acute respiratory infection (SARI) patients are limited. We conducted SARI surveillance in central China and estimated hospitalization rates of SARI attributable to influenza by viral type/subtype.MethodsSurveillance was conducted at four hospitals in Jingzhou, China from 2010 to 2012. We enrolled hospitalized patients who had temperature ≥37·3°C and at least one of: cough, sore throat, tachypnea, difficulty breathing, abnormal breath sounds on auscultation, sputum production, hemoptysis, chest pain, or chest radiograph consistent with pneumonia. A nasopharyngeal swab was collected from each case-patient within 24 hours of admission for influenza testing by real-time reverse transcription PCR.ResultsOf 17 172 SARI patients enrolled, 90% were aged <15 years. The median duration of hospitalization was 5 days. Of 16 208 (94%) SARI cases tested, 2057 (13%) had confirmed influenza, including 1427 (69%) aged <5 years. Multiple peaks of influenza occurred during summer, winter, and spring months. Influenza was associated with an estimated 115 and 142 SARI hospitalizations per 100 000 during 2010–2011 and 2011–2012 [including A(H3N2): 55 and 44 SARI hospitalizations per 100 000; pandemic A(H1N1): 33 SARI hospitalizations per 100 000 during 2010–2011; influenza B: 26 and 98 hospitalizations per 100 000], with the highest rate among children aged 6–11 months (3603 and 3805 hospitalizations per 100 000 during 2010–2011 and 2011–2012, respectively).ConclusionsIn central China, influenza A and B caused a substantial number of hospitalizations during multiple periods each year. Our findings strongly suggest that young children should be the highest priority group for annual influenza vaccination in China.

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“…The potential for bias is further compounded by age effects, which may impact both the likelihood of detection in surveillance systems and the probability of severe disease from infection. For example, while the majority of seasonal influenza A hospitalizations and deaths usually occur in the elderly, [4,5], evidence suggests that children are more likely to be infected [54], develop complications [55] and be hospitalized [56] for influenza B disease.…”

Section: Measuring Burden Of Diseasementioning

confidence: 99%

Key issues and challenges in estimating the impact and cost-effectiveness of quadrivalent influenza vaccination

Quinn

Jit

Newall

2014

Expert Review of Pharmacoeconomics & Outcomes Research

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Evidence has shown that quadrivalent influenza vaccines containing all four subtypes are safe and immunogenic. However, to date there have been few published studies exploring the population-level clinical and economic impact of quadrivalent compared to trivalent influenza vaccines. Economic evaluation studies need to be conducted in order to inform country-level decision making about whether (and how to) introduce and replace the current trivalent influenza vaccines with quadrivalent influenza vaccination programs. Several key issues associated with estimating the clinical and economic impact of the trivalent versus quadrivalent vaccines are discussed in this article, particularly the complexities involved in estimating the incremental preventable disease and economic burden. Other factors, such as the indirect (herd) protection from quadrivalent influenza vaccination and the timing of the replacement of trivalent influenza vaccination programs are also discussed.

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Development and Validation of a Risk Score for Predicting Hospitalization in Children With Influenza Virus Infection

Cited by 27 publications

References 36 publications

Predicting Need for Hospitalization of Patients with Pandemic (H1N1) 2009, Chicago, Illinois, USA

Predicting Need for Hospitalization of Patients with Pandemic (H1N1) 2009, Chicago, Illinois, USA

The substantial hospitalization burden of influenza in central China: surveillance for severe, acute respiratory infection, and influenza viruses, 2010–2012

Key issues and challenges in estimating the impact and cost-effectiveness of quadrivalent influenza vaccination

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