Development and Validation of a Nomogram-Based Prognostic Model to Predict High Blood Pressure in Children and Adolescents—Findings From 342,736 Individuals in China

Liang, Jinghong; Zhao, Yu; Chen, Yi-Can; Huang, Shan; Zhang, Shuxin; Jiang, Nan; Kakaer, Aerziguli; Chen, Yajun

doi:10.3389/fcvm.2022.884508

Cited by 8 publications

(4 citation statements)

References 57 publications

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“…Our data suggest that similar mechanisms may operate in younger patients. Despite the fact that a nomogram-based prognostic model indicates early life factors, family history, weight status, and lifestyle factors as predictors of hypertension in youth, our population did not show significant links between personal history and familial history for CVD and hypertension or cardiac damage [38]. However, a significant correlation was documented between BMI and cardiac mass, with cardiac mass being higher in patients with higher BMI, and this difference persisting over time.…”

Section: Discussioncontrasting

confidence: 75%

Body Mass Index (BMI) Is the Strongest Predictor of Systemic Hypertension and Cardiac Mass in a Cohort of Children

Fabi,

Meli,

Leardini

et al. 2023

Nutrients

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Background: Hypertension (HTN) is a well-established cardiovascular (CV) risk factor in adults. The presence of HTN in children appears to predict its persistence into adulthood. Early diagnosis of HTN is crucial to reduce CV morbidity before the onset of organ damage. Aim: The aim of this study is to investigate cardiac damage in HTN, its risk factors (RFs), and evolution. Methods: We conducted a prospective/retrospective study involving children referred to the Childhood Hypertension Outpatient Clinic. This study included clinical and echocardiographic assessments of cardiac morphology and function at three time points: enrollment (T0) and follow-up (T1 and T2). Results: Ninety-two patients (mean age 11.4 ± 3 years) were enrolled. Cardiac eccentric and concentric hypertrophy were present in 17.9% and 9%, respectively, with remodeling in 10.5%. Overweight/obese subjects exhibited significantly higher systolic blood pressure (SBP), frequency of HTN, and body mass index (BMI) at T0 compared with patients with chronic kidney disease (CKD). SBP and BMI persisted more during follow-up. Normal-weight vs. overweight/obese patients were significantly more likely to have normal geometry. Positive correlations were found between BMI and left ventricular (LV) mass at T0, BMI and SBP at T0 and T1. Gender, BMI, SBP, and diastolic blood pressure (DBP) significantly predicted LV mass index (LVMI), but only BMI added significance to the prediction. During follow-up, the variation of BMI positively correlated with the variation of SBP, but not with LVMI. Conclusions: In our cohort, body weight is strongly associated with HTN and cardiac mass. Importantly, the variation in body weight has a more significant impact on the consensual variation of cardiac mass than blood pressure (BP) values. A strict intervention on weight control through diet and a healthy lifestyle from early ages might reduce the burden of CV morbidity in later years.

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Section: Discussioncontrasting

confidence: 75%

Body Mass Index (BMI) Is the Strongest Predictor of Systemic Hypertension and Cardiac Mass in a Cohort of Children

Fabi,

Meli,

Leardini

et al. 2023

Nutrients

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“…Effects of wearing protective equipment and impacts of occupational noise at different frequencies and intensities on the cardiovascular system of workers deserve further exploration. Besides, we found a sex-dependent effect of noise on hypertension, which is consistent with the previous study (42). It may be related with the fact that the risk pattern for hypertension (43) and nature of the work (44) are different for male and female.…”

Section: Discussionsupporting

confidence: 92%

“…Available sociodemographic characteristics and clinical parameters were used in the nomograms, which was convenient and quick for screening the high-risk individuals. Previous nomogram suggests that age, sex, early life factors, family history of the disease, and lifestyle factors may predict the risk of hypertension (42,48). Given the research subjects of this study are workers exposed to occupational hazards and data limit, this study finally included age, sex, occupational noise exposure status and physical examination results.…”

Section: Discussionmentioning

confidence: 99%

Relationship between occupational noise exposure and hypertension: Cross-sectional evidence from real-world

Zhang

Chen

et al. 2022

Front. Public Health

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BackgroundOccupational noise is one of the most common and prevalent occupational hazards worldwide and may induce adverse auditory and/or non-auditory health effects. However, the relationship between occupational noise exposure and hypertension is controversial and has long been debated.MethodsBased on large sample cross-sectional data from all registered occupational health examination units from 2021 to 2022 (N = 101,605), this study aimed to analyze the prevalence of hearing loss and hypertension and to explore the influencing factors of hypertension of workers in Wuhan. Descriptive statistics, univariate analyses and multivariate analyses were used. Forest plot and nomograms were constructed for the visualization of predictive results. The ROC curve, AUC, C-index and calibration curves were used to assess the predictive accuracy and validity. DCA was performed to evaluate the net benefit that workers could receive.ResultsHigher rate of high-frequency hearing loss (25.3%), speech frequency hearing loss (8.8%), ECG abnormalities (31.9%) and hypertension (21.0%) were found in workers exposed to occupational noise in Wuhan. Occupational noise exposure (OR = 1.09, 95% CI: 1.01–1.18, p = 0.04), growth of age (OR: 1.07, 95% CI: 1.07–1.07, p < 0.001), overweight (OR: 1.82, 95% CI: 1.73–1.92, p < 0.001), obesity (OR: 3.62, 95% CI: 3.42–3.83, p < 0.001), hyperglycemia (OR: 1.84, 95% CI: 1.73–1.96, p < 0.001), hypercholesterolemia (OR = 1.34; 95% CI 1.22–1.48; p < 0.001), ECG abnormalities (OR = 1.11; 95% CI 1.07–1.15; p < 0.001) and family history of hypertension (OR = 1.69; 95% CI 1.58–1.81; p < 0.001) were risk factors of hypertension for workers. Male workers had a relatively higher hypertension risk than female workers (OR = 1.61; 95% CI 1.54–1.69; p < 0.001). Ear protective measures could not reduce the risk of hypertension in workers. Our nomogram has good predictive accuracy and validity. A dynamic nomogram to predict the workers' risk of hypertension was established publicly available online.ConclusionOccupational noise exposure may elevate workers' hypertension risk. More effective and relevant prevention measures should be taken. Our nomogram may help identify high-risk workers and facilitate timely interventions.

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“…Therefore, a predictive model to identify the patients suffering the high risk and predict DVT early might help clinicians to take prophylactic measures to reduce the incidence of DVT and avoid unnecessary examination. Notably, the nomogram model is a novel and convenient tool and has been widely used to predict outcomes and complications in various diseases [ 7 – 11 ]. To date, several investigations have evaluated the risk factors of venous thromboembolism [ 3 – 5 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Development and validation of a nomogram for predicting deep venous thrombosis in patients with pelvic and acetabular fractures: a retrospective cohort study

Yang,

Rongqing,

Yang

et al. 2023

BMC Musculoskelet Disord

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Purpose To construct a novel nomogram model that can predict DVT and avoid unnecessary examination. Methods Patients admitted to the hospital with pelvis/acetabular fractures were included between July 2014 and July 2018. The potential predictors associated with DVT were analyzed using Univariate and multivariable logistic regression analysis. The predictive nomogram was constructed and internally validated. Results 230 patients were finally enrolled. There were 149 individuals in the non-DVT group and 81 in the DVT group. Following analysis, we obtained the final nomogram model. The risk factors included age (OR, 1.037; 95% CI, 1.013–1.062; P = 0.002), body mass index (BMI) (OR, 1.253; 95% CI, 1.120–1.403; P < 0.001); instant application of anticoagulant after admission (IAA) (OR, 2.734; 95% CI, 0.847–8.829; P = 0.093), hemoglobin (HGB) (OR, 0.970; 95% CI, 0.954–0.986; P < 0.001), D-Dimer(OR, 1.154; 95% CI, 1.016–1.310; P = 0.027) and fibrinogen (FIB) (OR, 1.286; 95% CI, 1.024–1.616; P = 0.002). The apparent C-statistic was 0.811, and the adjusted C-statistic was 0.777 after internal validations, demonstrating good discrimination. Hosmer and Lemeshow’s goodness of fit (GOF) test of the predictive model showed a good calibration for the probability of prediction and observation (χ2 = 3.285, P = 0.915; P > 0.05). The decision curve analysis (DCA) and Clinical impact plot (CIC) demonstrated superior clinical use of the nomogram. Conclusions An easy-to-calculate nomogram model for predicting DVT in patients with pelvic-acetabular fractures were developed. It could help clinicians to reduce DVT and avoid unnecessary examinations.

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Development and Validation of a Nomogram-Based Prognostic Model to Predict High Blood Pressure in Children and Adolescents—Findings From 342,736 Individuals in China

Cited by 8 publications

References 57 publications

Body Mass Index (BMI) Is the Strongest Predictor of Systemic Hypertension and Cardiac Mass in a Cohort of Children

Body Mass Index (BMI) Is the Strongest Predictor of Systemic Hypertension and Cardiac Mass in a Cohort of Children

Relationship between occupational noise exposure and hypertension: Cross-sectional evidence from real-world

Development and validation of a nomogram for predicting deep venous thrombosis in patients with pelvic and acetabular fractures: a retrospective cohort study

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