Development and validation of a UPLC–MS/MS method for quantitation of droxidopa in human plasma: Application to a pharmacokinetic study

Wang, Haidong; Yang, Guangsheng; Zhou, Jianqin; Jiang, Pei; Zhang, Qiangfeng; Song, Xingfa; Sun, Zengxian

doi:10.1016/j.jchromb.2016.04.056

Cited by 9 publications

(5 citation statements)

References 19 publications

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“…For the purpose of determining the qualitative and/or quantitative analysis and composition of postbiotics, a number of analytical techniques, including gas chromatography (GC), high-performance liquid chromatography (HPLC), thin-layer chromatography (TLC), and spectroscopic methods, have been reviewed in detail [ 68 , 90 , 91 , 92 ]. Owing to its high efficiency, resolution, sensitivity, accuracy, and low solvent usage, ultra-performance liquid chromatography offers superior postbiotic separation and identification capabilities [ 93 , 94 , 95 ]. Thin-layer chromatography has been used to determine whether postbiotics contain various compounds [ 96 , 97 ].…”

Section: Production Purification and Characterization Of Postbioticsmentioning

confidence: 99%

Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases

Gurunathan,

Thangaraj,

Kim

2023

Foods

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Postbiotics are (i) “soluble factors secreted by live bacteria, or released after bacterial lysis, such as enzymes, peptides, teichoic acids, peptidoglycan-derived muropeptides, polysaccharides, cell-surface proteins and organic acids”; (ii) “non-viable metabolites produced by microorganisms that exert biological effects on the hosts”; and (iii) “compounds produced by microorganisms, released from food components or microbial constituents, including non-viable cells that, when administered in adequate amounts, promote health and wellbeing”. A probiotic- and prebiotic-rich diet ensures an adequate supply of these vital nutrients. During the anaerobic fermentation of organic nutrients, such as prebiotics, postbiotics act as a benevolent bioactive molecule matrix. Postbiotics can be used as functional components in the food industry by offering a number of advantages, such as being added to foods that are harmful to probiotic survival. Postbiotic supplements have grown in popularity in the food, cosmetic, and healthcare industries because of their numerous health advantages. Their classification depends on various factors, including the type of microorganism, structural composition, and physiological functions. This review offers a succinct introduction to postbiotics while discussing their salient features and classification, production, purification, characterization, biological functions, and applications in the food industry. Furthermore, their therapeutic mechanisms as antibacterial, antiviral, antioxidant, anticancer, anti-diabetic, and anti-inflammatory agents are elucidated.

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Section: Production Purification and Characterization Of Postbioticsmentioning

confidence: 99%

Postbiotics: Functional Food Materials and Therapeutic Agents for Cancer, Diabetes, and Inflammatory Diseases

Gurunathan,

Thangaraj,

Kim

2023

Foods

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“…Depending on the analytical objectives and qualitative and/or quantitative properties of microbial metabolite complexes, many analytical approaches are now being employed to identify postbiotic metabolites (Cuevas-Gonzalez et al, 2020). For the purpose of determining the qualitative and/or quantitative analysis and composition of postbiotics, a number of analytical techniques, including gas chromatography (GC), high-performance liquid chromatography (HPLC), thin-layer chromatography (TLC), and spectroscopic methods, have been reviewed in detail (Ruas-Madiedo et al, 2005;Moradi et al, 2021;Lee et al, 2012;Garnier et al Because of its high efficiency, resolution, sensitivity, and accuracy as well as its little solvent usage, ultra-performance liquid chromatography offers superior postbiotic separation and identification capabilities (Lin and Pan, 2019;Lim et al, 2018;Wang et al, 2016). Thin layer chromatography has been used to determine that postbiotics contain a variety of compounds (Sharma et al, 2015;Wang et al, 2012).…”

Section: Production Purification and Characterization Of Postbioticsmentioning

confidence: 99%

Postbiotics- Functional Food Materials

Gurunathan,

Thangaraj,

Kim

2023

Preprint

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Postbiotics are biologically active probiotic microorganisms that have produced non-viable bacterial products in the host. Eating a diet high in probiotic and prebiotic foods may help to ensure that the gut has an appropriate supply of these essential nutrients because postbiotics are produced when probiotics feed on prebiotics. Cell wall components and metabolites produced by living bacteria that have positive effects on the host are referred to as postbiotics. Postbiotics are functional bioactive chemicals that are produced in a matrix during anaerobic fermentation of organic nutrients like prebiotics. Postbiotics are low molecular weight soluble chemicals that are either produced after microbial cell lysis or secreted by live microflora as byproducts of this metabolic process. In general, the producer strains from bacterial and fungal species such as Lactobacillus, Bifidobacterium, Streptococcus, Akkermansia muciniphila, Saccharomyces boulardii, Eubacterium hallii, Faecalibacterium, etc. When handling and selling food items in an industrial setting, postbiotics can be used as functional components in foods, which has a number of advantages, including the potential to be added to some foods that are known to be harmful to probiotic survival. Postbiotic supplements have grown in popularity among customers because of their numerous health advantages, particularly food, cosmetic, and healthcare industries. Classification of postbiotics depends on various factors including type of microorganism, structural composition, and physiological functions. This review presents a succinct introduction, history, and concept of postbiotics, the salient features of postbiotics, classification, production, purification, characterization, biological functions, and applications of postbiotics in the food industry.

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“…Droxidopa was recently approved by the FDA after 3 randomized double-blind studies demonstrated impressive improvement in both symptoms as well as BP parameters [25]. Droxidopa is a safe, synthetic prodrug of norepinephrine, reaching peak plasma concentration in 2 hours [26,27]. Droxidopa can be dosed at 100–600 mg per doses, given 2–3 times per day [18].…”

Section: Treatment/management (Figure 2)mentioning

confidence: 99%