Development and Validation of an Analytical Method for the Detection and Quantification of Bromazepam, Clonazepam and Diazepam by UPLC-MS/MS in Surface Water

Benzodiazepines in complex biological matrices: Recent updates on pretreatment and detection methods

“…[ 86 ] applied Strata-X-C mixed-mode SPE cartridges for extracting midazolam from rabbit plasma with recoveries of 82.1%–109.7%. SPE in pretreating BDZs is summarized in Table S2 [ 35 , 37 , 50 , 67 , [86] , [87] , [88] , [89] , [90] , [91] , [92] , [93] , [94] , [95] , [96] , [97] , [98] , [99] , [100] ].…”

“…LC is a widely used analytical technique for separations based on the selectivity of components in the mixture for the stationary and mobile phases. The application of the LC method for BDZs is shown in Table S5 [ [21] , [22] , [23] , [24] , [27] , [28] , [29] , [30] , 32 , 34 , [39] , [40] , [41] , [42] , [44] , [45] , [46] , [47] , 49 , 51 , [58] , [59] , [60] , [61] , 63 , 65 , [69] , [70] , [71] , [73] , [74] , [75] , [76] , [77] , [78] , 81 , [87] , [88] , [89] , [90] , [91] , [92] , [93] , [95] , [96] , [97] , [98] , [99] , [100] , [101] , [102] , [104] , [105] , [106] , [107] , [109] , [110] , [111] , [112] , 115 , [119] , [120] , [121] , …”

Polystyrene nanofibers as an effective sorbent for the adsorption of clonazepam: kinetic and thermodynamic studies

“…Commercial SPE cartridges [24][25][26] have been used to extract clonazepam from water or biological samples, and good extraction recoveries have been obtained. However, no adsorption experiment has been done by using commercial SPE cartridges, most of the commercial SPE adsorbents are carbon-based materials with the particle size of the packing is generally micron level, the specic surface area of the material is small, and the adsorption efficiency is generally not high.…”

Degradation of Diazepam with Gamma Radiation, High Frequency Ultrasound and UV Radiation Intensified with H2O2 and Fenton Reagent

“…Many investigations report the inefficiency of conventional wastewater treatment plants for eliminating persistent pollutants, and as a result, the presence of contaminants in effluent from treatment plants, rivers, lakes, and to a lesser extent in groundwater [1]. Diazepam (DZP) is the most prescribed benzodiazepine for its hypnotic, tranquilizing, and anticonvulsive properties, with levels in water bodies varying from 10 ng L −1 to 1 µg L −1 [6][7][8][9][10][11][12]. The presence of benzodiazepines affects the ecosystems in different ways [13,14].…”