Development and validation of ferroptosis-related lncRNA signature and immune-related gene signature for predicting the prognosis of cutaneous melanoma patients

Xiong, Kaifen; Wang, Zheng; Hounye, Alphonse Houssou; Peng, Li; Zhang, Jianglin; Qi, Min

doi:10.1007/s10495-023-01831-7

Cited by 6 publications

(2 citation statements)

References 77 publications

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“…Secondly, targeting ferroptosis may enhance treatment efficacy and improve patient outcomes [ 278 , 311 ]. Given the significant role of ferroptosis in tumor growth, invasion, and metastasis, interventions that interfere with tumor cell iron metabolism and induce ferroptosis have the potential to effectively suppress tumor progression and dissemination, thereby improving treatment responses and prognoses, ultimately leading to better survival rates and quality of life for patients [ 312 , 313 ]. Furthermore, targeting ferroptosis could offer new avenues for personalized cancer therapy [ 314 ].…”

Section: Ferroptosis In Pathologiesmentioning

confidence: 99%

The mechanism of ferroptosis and its related diseases

Feng,

Tang,

Wang

et al. 2023

Mol Biomed

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Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of cellular metabolism, oxidative stress, and disease pathology. We have witnessed a mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological and pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, and traumatic tissue injuries. By unraveling the intricate underpinnings of the molecular machinery, pivotal contributors, intricate signaling conduits, and regulatory networks governing ferroptosis, researchers aim to bridge the gap between the intricacies of this unique mode of cellular death and its multifaceted implications for health and disease. In light of the rapidly advancing landscape of ferroptosis research, we present a comprehensive review aiming at the extensive implications of ferroptosis in the origins and progress of human diseases. This review concludes with a careful analysis of potential treatment approaches carefully designed to either inhibit or promote ferroptosis. Additionally, we have succinctly summarized the potential therapeutic targets and compounds that hold promise in targeting ferroptosis within various diseases. This pivotal facet underscores the burgeoning possibilities for manipulating ferroptosis as a therapeutic strategy. In summary, this review enriched the insights of both investigators and practitioners, while fostering an elevated comprehension of ferroptosis and its latent translational utilities. By revealing the basic processes and investigating treatment possibilities, this review provides a crucial resource for scientists and medical practitioners, aiding in a deep understanding of ferroptosis and its effects in various disease situations.

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Section: Ferroptosis In Pathologiesmentioning

confidence: 99%

The mechanism of ferroptosis and its related diseases

Feng,

Tang,

Wang

et al. 2023

Mol Biomed

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“…Recently published papers indicate the involvement of lncRNAs in tumor microenvironment maintenance and immunotherapy efficacy in melanoma ( Zhou et al, 2022 ; Xiong et al, 2023 ). The upregulation of SMG7-AS1 has been implicated in melanoma progression, since this lncRNA controls apoptosis cell cycle and metastatic potential of tumor cells.…”

Section: Lncrnas In Health and Diseasementioning

confidence: 99%

lncRNAs-EZH2 interaction as promising therapeutic target in cutaneous melanoma

Wozniak

Czyż

2023

Front. Mol. Biosci.

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Melanoma is the most lethal skin cancer with increasing incidence worldwide. Despite a great improvement of diagnostics and treatment of melanoma patients, this disease is still a serious clinical problem. Therefore, novel druggable targets are in focus of research. EZH2 is a component of the PRC2 protein complex that mediates epigenetic silencing of target genes. Several mutations activating EZH2 have been identified in melanoma, which contributes to aberrant gene silencing during tumor progression. Emerging evidence indicates that long non-coding RNAs (lncRNAs) are molecular “address codes” for EZH2 silencing specificity, and targeting lncRNAs-EZH2 interaction may slow down the progression of many solid cancers, including melanoma. This review summarizes current knowledge regarding the involvement of lncRNAs in EZH2-mediated gene silencing in melanoma. The possibility of blocking lncRNAs-EZH2 interaction in melanoma as a novel therapeutic option and plausible controversies and drawbacks of this approach are also briefly discussed.

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