Development and Validation of First Order Derivative Uv Spectrophotometric Method for Simultaneous Estimation of Propranolol Hydrochloride and Flunarizine Dihydrochloride in Bulk and Combined Dosage Form

Wagh, Dipmala Dilip; Deshmukh, Vishakha Vijay; Vassa, Swetal P.; Jain, Hemant Kumar

doi:10.7897/2230-8407.04639

Cited by 2 publications

(1 citation statement)

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“…Since baseline drift and interference with carbonyl stretching signal limit IR suitability for quantitative analysis, the first derivative of the spectra was employed. Mathematical derivatization minimizes the baseline drift and anomaly of the spectrum [ 46 – 48 ]. And also it enhances the selectivity of the analysis due to the improvement of the peak shape and resolution [ 46 ].…”

Section: Resultsmentioning

confidence: 99%

The Development and Application of Novel IR and NMR-Based Model for the Evaluation of Carminative Effect ofArtemisia judaicaL. Essential Oil

Alzweiri

Al-Rawashdeh

Bardaweel

2014

International Journal of Analytical Chemistry

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Artemisia judaica L. is a medicinal plant that is traditionally used to relieve abdominal pains through its carminative activity. In this study, spectroscopic analysis was employed to investigate the carminative activity associated with A. judaica. Using infrared spectroscopy, the carminative activity was evaluated based on the first derivative of IR-characteristic stretching signal of CO2. Our results indicate that A. judaica oil effectively reduced the response of CO2 signal equivalent to thymol standard. Additionally, 1H-NMR spectroscopy was utilized to assess surface activity of A. judaica crude oil through the reduction of interfacial tension in a D2O/CDCl3 system. Apparently, 10 mg of the oil was able to solubilize water in a chloroform layer up to 4.3% (w/w). In order to correlate the observed surface activity of the oil to its actual composition, GC-MS and GC-FID structural analysis were undertaken. The results revealed that the oil composition consists of oxygenated terpenes which might be responsible for the carminative effect. Furthermore, owing to its sensitivity, our model provides a fundamental basis for the pharmacological assessment of trace amounts of oils with high precision and accuracy.

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Section: Resultsmentioning

confidence: 99%

The Development and Application of Novel IR and NMR-Based Model for the Evaluation of Carminative Effect ofArtemisia judaicaL. Essential Oil

Alzweiri

Al-Rawashdeh

Bardaweel

2014

International Journal of Analytical Chemistry

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A review on analytical methods of cilnidipine and its combinations

Mishra

Mehta

2022

EJPPS

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Background - The chase to improve the quality of life has stimulated desirable changes in research to design and develop a new drug and enhance its safety and effectiveness. Thus, there is a gradual rise in demand to develop susceptible and specific analytical techniques for newly developed drugs. Thus, analysts are striving very hard to develop new and efficient analytical methods to achieve these targets. Main body of abstract - Analytical methods that analyze drug compounds in a given matrix need to be optimized and validated to ensure excellent selectivity, sensitivity, ease of use, speed of analysis, less expensive, and efficient analytical procedures. Developing a new analytical method should be considered critical, based on availability and accurate handling of different instruments. This review is a genuine venture of compiled literature of earlier and recent trends in the method developments for Cilnidipine (CLD) analysis alone and in combination with other drugs. It provides an in-depth assortment of practical aspects of various analytical techniques published for CLD. Conclusion - High-performance liquid chromatography and ultraviolet spectroscopy have been found the most acceptable for the analysis of CLD. Stability indicating studies and impurity profiling of CLD also prevailed in the assembled literature. Scanty work was observed with capillary electrophoresis, Fourier transform-infrared spectroscopy, and electroanalytical methods to analyze CLD. Applications mentioned for CLD are significant in their particular field and contribute to analytical assay in future endeavours. Keywords- Cilnidipine, Bioanalytical method, Stability indicating method, HPLC, Spectrophotometry.

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Development and Validation of First Order Derivative Uv Spectrophotometric Method for Simultaneous Estimation of Propranolol Hydrochloride and Flunarizine Dihydrochloride in Bulk and Combined Dosage Form

Cited by 2 publications

References 4 publications

The Development and Application of Novel IR and NMR-Based Model for the Evaluation of Carminative Effect ofArtemisia judaicaL. Essential Oil

The Development and Application of Novel IR and NMR-Based Model for the Evaluation of Carminative Effect ofArtemisia judaicaL. Essential Oil

A review on analytical methods of cilnidipine and its combinations

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