Development and validation of prognostic index based on autophagy-related genes in patient with head and neck squamous cell carcinoma

Abstract

Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers worldwide, accounting for almost 50% of all malignancies in developing nations. Autophagy plays a vital role in cancer initiation, malignant progression, and resistance to treatment. However, autophagy-related gene sets have rarely been analyzed in HNSCC. Hence, it is necessary to assess its clinical and pathological significance in a larger cohort of patients with HNSCC. The purpose of this study was to establish a novel autophagy-related prognostic marker for HNSCC. We screened 232 autophagy-related genes (ARGs) and identified 38 differentially expressed ARGs in The Cancer Genome Atlas (TCGA) cohorts. The prognosis-related ARGs signature, established using the univariate and multivariate Cox proportional regression models, consists of 10 ARGs that could divide patients into high-risk and low-risk groups. Survival analysis indicated that patients in the high-risk group had dramatically shorter overall survival compared with their low-risk counterparts. Cox regression analysis further confirmed the independent prognostic value of the autophagy-related signature, and the area under the receiver operating characteristic curve of the combined prognostic model was 0.722. Finally, the efficacy of autophagy-related signature was also validated by an independent cohort from the Gene Expression Omnibus (GEO) database. Collectively, we successfully constructed a novel autophagy-related signature for the prediction of prognosis in patients with HNSCC.

Identification and validation of autophagy-related prognostic signature for head and neck squamous cell carcinoma

“…Feng et al. [30] constructed a model of ARGs and showed the interface between risk signature and OS. However, a comprehensive exploration of ARGs in the TIME, the value of HPV status in risk signature, the analysis of DSS, is lacking.…”

Novel Autophagy-Related Gene Signature Investigation for Patients With Oral Squamous Cell Carcinoma

“…It has been reported that NRG3 is associated with the risk and age at onset of Alzheimer's disease (Wang et al, 2014). NRG3 was recently identified as a prognostic index for inpatients with head and neck squamous cell carcinoma (Feng et al, 2020).…”

Development and Validation of a Hypoxia-Related Gene Pairs Signature to Predict Overall Survival in Head and Neck Squamous Cell Carcinoma

“…In order to show that our prognostic model is superior to other models, we compared the HRGP prognostic signature with three published signatures [19][20][21], all data are from TCGA. As we thought, the cindex of the prognostic signature in this study was 0.684, and the HRGP prognostic signature was higher than the existing autophagy-related prognostic signature (c-index = 0.637), the immune-related gene prognostic signature (c-index = 0.592 ) and the RNA-binding protein-related gene prognostic signature (cindex = 0.57) have higher clinical application value.…”