Development and validation of SARMs and metabolic modulators screening in hair using UHPLC-MS/MS: Application to a doping case and first identification of S23 in authentic human hair

Detection of the growth hormone secretagogue MK‐0677 in equine hair following oral administration

“…Extraction and analysis of negative and positive control samples showed that the method was selective for MK‐0677 and its O ‐dealkylated metabolite with no co‐eluting matrix peaks observed (Figure 2). MK‐0677 was detected in the hair sample spiked at 0.5 pg/mg with a recovery of 46%, which is similar to what has previously been reported for MK‐0677 (53%) in human hair 17 . The recovery of the O ‐dealkylated was 38%.…”

“…MK-0677 was detected in the hair sample spiked at 0.5 pg/mg with a recovery of 46%, which is similar to what has previously been reported for MK-0677 (53%) in human hair. 17 The recovery of the O-dealkylated was 38%. Estimated limit of detection of MK-0677 was extrapolated to be 0.1 pg/mg, which is considerably lower than previously reported at 5 pg/mg for human hair.…”

“…Estimated limit of detection of MK-0677 was extrapolated to be 0.1 pg/mg, which is considerably lower than previously reported at 5 pg/mg for human hair. 17 Therefore, the method was demonstrated to be suitable for qualitative analysis of equine hair samples.…”

A screening method for the quantitative determination of selective androgen receptor modulators (SARMs) in capsules by high resolution 19F- and 1H-NMR spectroscopy

“…In the literature, analytical methods based on hyphenated techniques liquid or gas chromatography and mass spectrometryhave been reported for the analysis of SARMs in tablets, powders, liquids, and capsules. [13][14][15][16] These methods have the advantage of good sensitivity but require the use of specic reference standards for quantication and of standards or databases for identication. Reference standards are oen expensive and not always available.…”

Annual banned‐substance review—Analytical approaches in human sports drug testing 2021/2022–

“…Studies ranged from structuring athletic characteristics of sport disciplines 10 and the consideration of the athlete's performance passport 11 for optimized test distribution plans and menus (as exemplified by an evaluation of weightlifting performances among two groups of athletes that were either sanctioned due to AAFs or not) to assessing the utility, advantages, and limitations of alternative matrices. Among those, the recently approved use of dried blood spots (DBSs) 12 warrants mentioning due to the growing attention and promise of DBS applications in sports drug testing, 13 but also hair 14 and exhaled breath 15 were shown to allow for complementary information, potentially qualifying for future routine doping controls and/or case‐related follow‐up investigations.…”