Development and Validation of the Quantitative Analysis of Ceftazidime in Powder for Injection by Infrared Spectroscopy&lt;SUP&gt;#&lt;/SUP&gt;

Moreno, Andréia de Haro; Salgado, Hérida Regina Nunes

doi:10.5923/j.pc.20120201.02

Cited by 33 publications

(6 citation statements)

References 56 publications

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“…3b) and CP (Fig. 3c) were in good agreement with those previously reported for fluoroquinolone and cephalosporin antibiotics [32,33]. In the FT-IR spectrum of ZnO-CP ( Fig.…”

Section: Interaction Studies Of Zno Nps With Antibioticssupporting

confidence: 90%

In vitro antibacterial activity of ceftazidime, unlike ciprofloxacin, improves in the presence of ZnO nanofluids under acidic conditions

Bafekr

Jalal

2018

IET nanobiotechnol.

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The development of antibiotic resistance among hospital pathogens has provided a great need for new antimicrobial agents. Zinc oxide nanoparticles (ZnO NPs) in combination with various antibiotics can act as a reducing agent for antibiotic resistance. The aim of this study was to investigate the influence and the mechanism of ZnO NPs on the antimicrobial activity of ciprofloxacin (CP) and ceftazidime (CAZ) against () and () bacteria in acidic conditions (pH 5.5). ZnO NPs were synthesised using the solvothermal method and characterised. The MIC90 value of ZnO NPs against was 0.25 mg ml and its highest growth-inhibitory activity was observed at 0.125 mg ml for The Fourier transform infrared spectroscopy spectra of ZnO NPs treated with antibiotics showed the interaction between ZnO NPs and each of the two antibiotics. ZnO NPs at a sub-inhibitory concentration had no effect on the antibacterial activity of CP and CAZ against and CP against The action mechanism of ZnO NPs for enhancing the antibacterial efficacy of CAZ against was evaluated. ZnO NPs caused to increase in the antibacterial activity of CAZ against , possibly through the release of Zn and increasing of membrane permeability.

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“…3b) and CP (Fig. 3c) were in good agreement with those previously reported for fluoroquinolone and cephalosporin antibiotics [32,33]. In the FT-IR spectrum of ZnO-CP ( Fig.…”

Section: Interaction Studies Of Zno Nps With Antibioticssupporting

confidence: 90%

In vitro antibacterial activity of ceftazidime, unlike ciprofloxacin, improves in the presence of ZnO nanofluids under acidic conditions

Bafekr

Jalal

2018

IET nanobiotechnol.

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“…Figure 6 displays the measured spectra of virgin PLGA microparticles and antibiotic/analgesic-loaded PLGA microparticles. The new absorption peak at 3200~3500 cm −1 could be attributable to the N–H bonds of vancomycin, ceftazidime, and lidocaine [26,27,28]. The absorption at 1725 cm −1 corresponded to C=O bonds, primarily due to the addition of antibiotics and analgesic; the absorbance peak near 1300 cm −1 may be the result of C–O bond enhancement in loaded pharmaceuticals.…”

Section: Resultsmentioning

confidence: 99%

Sustained Delivery of Analgesic and Antimicrobial Agents to Knee Joint by Direct Injections of Electrosprayed Multipharmaceutical-Loaded Nano/Microparticles

Hsu

Chen

et al. 2018

Polymers

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Abstract:In this study, we developed biodegradable lidocaine-/vancomycin-/ceftazidime-eluting poly(D,L-lactide-co-glycolide) (PLGA) nano/microparticulate carriers using an electrospraying process, and we evaluated the release behaviors of the carriers in knee joints. To prepare the particles, predetermined weight percentages of PLGA, vancomycin, ceftazidime, and lidocaine were dissolved in solvents. The PLGA/antibiotic/lidocaine solutions were then fed into a syringe for electrospraying. After electrospraying, the morphology of the sprayed nano/microparticles was elucidated by scanning electron microscopy (SEM). The in vitro antibiotic/analgesic release characteristics of the nano/microparticles were studied using high-performance liquid chromatography (HPLC). In addition, drug release to the synovial tissues and fluids was studied in vivo by injecting drug-loaded nano/microparticles into the knee joints of rabbits. The biodegradable electrosprayed nano/microparticles released high concentrations of vancomycin/ceftazidime (well above the minimum inhibition concentration) and lidocaine into the knee joints for more than 2 weeks and for over 3 days, respectively. Such results suggest that electrosprayed biodegradable nano/microcarriers could be used for the long-term local delivery of various pharmaceuticals.

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“…The accuracy of an analytical procedure communicates the closeness of understanding between the worth which is acknowledged either as a traditional genuine value or an acknowledged reference value and the value found. This is often termed trueness [21].…”

Section: Ftir Spectrum Of Sample N-(26-dimethylphenyl)-2-{[5-(1h-indol-3-ylmethyl) Oxadiazol-2-yl]sulfanyl} Acetamidementioning

confidence: 99%

“…between the worth which is acknowledged either as a traditional genuine value or an acknowledged reference value and the value found. This is often termed trueness [21]. he accuracy analysis was carried out at three levels 80, 100, and 120 %.…”

Section: Ylmethyl)-134-mentioning

confidence: 99%

Method to Develop and Stress Degradation Profile of N-(2,6-dimethylphenyl)-2-{[5-(1H-indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}Acetamide Studied by UV Spectroscopy

Afridi

Latif

Fahham

et al. 2021

JPRI

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Background: Synthetic chemistry has always served as a back bone to the medicinal and pharmaceutical chemistry in terms of drug development and drug optimization. It helped in a great deal in finding new lead compounds and synthesizing new drugs. A new molecule N-(2,6-Dimethylphenyl)-2-{[5-(1H-indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl] sulfanyl} acetamide, was synthesized from the fusion of Indole acetic acid with 1,3,4-oxadiazole. This pharmacologically active entity lacks a suitable method for its analysis. Aim: The present research aimed to develop a UV visible spectroscopic method for the purpose followed by its validation according to ICH guidelines. Methodology: The method was developed at 225 nm (λmax). Then the accuracy, precision, sensitivity (Limit of detection & Limit of quantification), specificity, robustness and ruggedness were calculated. The analyte was exposed to multiple stress conditions to figure out method’s specificity. Results: The developed method showed the linearity within a range (0.5 – 50 µg/mL) with correlation coefficient (R2) = 0.9997. The accuracy of the developed method was figured out by recovery analysis and it was within 95.556 – 104.321 %. The precision analysis i.e. interday (0.505591 %), intraday (0.231661 %) and repeatability (0.06478 %), were within the acceptance criteria viz. % RSD less than 2 % and LOD & LOQ were found to be 0.523356 and 1.58598 µg/mL. All the validation parameters were within the acceptance limits making the method unique and acceptable. In addition to that it was found to be easy, reliable and analyst friendly (ruggedness, 0.520889 %). The analyte when exposed to stress conditions viz. acidic (0.1N H2SO4) and basic (0.1N NaOH) environment, oxidative stress (3 % H2O2), UV light and altered temperature and humidity (80 ºC+75% RH) for 24 hr, it was found deteriorated. The analyte was 65.56 % degraded in acidic, 39.63 % in basic, 45.18 % under oxidative stress and 61.85 % under altered conditions of temperature and humidity. There was a complete loss of analyte (87.78 %) when exposed to UV light. Conclusion: The results clearly states that the method is simple, sensitive, specific, precise and accurate, thus can be employed for the quantitative estimations of the analyte.

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Development and Validation of the Quantitative Analysis of Ceftazidime in Powder for Injection by Infrared Spectroscopy<SUP>#</SUP>

Cited by 33 publications

References 56 publications

In vitro antibacterial activity of ceftazidime, unlike ciprofloxacin, improves in the presence of ZnO nanofluids under acidic conditions

In vitro antibacterial activity of ceftazidime, unlike ciprofloxacin, improves in the presence of ZnO nanofluids under acidic conditions

Sustained Delivery of Analgesic and Antimicrobial Agents to Knee Joint by Direct Injections of Electrosprayed Multipharmaceutical-Loaded Nano/Microparticles

Method to Develop and Stress Degradation Profile of N-(2,6-dimethylphenyl)-2-{[5-(1H-indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl}Acetamide Studied by UV Spectroscopy

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