Development and validation of the chronic hepatitis C virus treatment satisfaction (HCVTSat) instrument

Szeinbach, Sheryl L.; Baran, Robert W.; Dietz, Birgitta; Rocca, L. Gazzouola; Littlefield, Dawn; Yawn, Barbara P.

doi:10.1111/apt.12202

Aliment Pharmacol Ther

2013

DOI: 10.1111/apt.12202

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Development and validation of the chronic hepatitis C virus treatment satisfaction (HCVTSat) instrument

Sheryl L. Szeinbach

Robert W. Baran

Birgitta Dietz

et al.

Abstract: SUMMARY BackgroundWhile current medications used to treat patients with chronic hepatitis C virus (HCV) effectively produce sustained viral response (SVR), postponement of therapy is oftentimes attributed to patient perceptions of unfavourable outcomes. However, an instrument to assess patient perceptions of therapy (i.e. treatment satisfaction) has not been developed.

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Cited by 5 publications

(2 citation statements)

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“…We read with great interest the article by Szeinbach et al . in which the development of the chronic hepatitis C virus (HCV) treatment satisfaction (HCVTSat) instrument is described . There is a high prevalence of depression and anxiety in HCV, and this depression is accompanied by an increased risk of adverse experience with illness …”

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Commentary: the chronic hepatitis C virus treatment satisfaction (HCVTSat) instrument

Kappus

Bajaj

2013

Aliment Pharmacol Ther

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We read with great interest the article by Szeinbach et al. in which the development of the chronic hepatitis C virus (HCV) treatment satisfaction (HCVTSat) instrument is described.1 There is a high prevalence of depression and anxiety in HCV, and this depression is accompanied by an increased risk of adverse experience with illness. Interferon-based therapy can add substantially to this mental health burden, which compounds the pre-existing effect of HCV on quality of life including fear of the disease or effects of treatment as well as socio-economic ramifications.3, 4 While instruments to assess 'functional status' during and following HCV treatment exist, there remains a need to develop and validate patient-centred surveys focused on quality of life, expectations and experienced or perceived issues with HCV therapy. Assessing satisfaction might bridge gaps to earlier adoption of treatment by patients, instead of waiting for the development of cirrhosis which can occur in 20% of patients. 5The questionnaire used has been developed from the patient's perspective, and focuses on HCV therapy perception using valid techniques. These types of tools are necessary for forming a therapeutic alliance between patient and clinician by fostering understanding of patient-related concerns. The 10-question instrument, however, was based on predominantly Caucasian, tertiary-care patients, three-quarters of whom were insured. Furthermore, only 21% of patients were undergoing treatment, and influence of HCV genotype was not studied.As a result, further work is needed to make this truly representative of the current HCV patient population. However, this paper introduces a relatively easy method to measure patient-perceived treatment satisfaction in HCV. As options for treatment evolve, especially in the era of direct-acting anti-virals, patient-centred instruments will be important to understand the factors involved in influencing therapy selection, and may potentially prevent therapy dropouts. ACKNOWLEDGEMENTDeclaration of personal and funding interests: None.

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Commentary: the chronic hepatitis C virus treatment satisfaction (HCVTSat) instrument

Kappus

Bajaj

2013

Aliment Pharmacol Ther

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“…We greatly appreciated the thought‐provoking comments provided by Drs Kappus and Bajaj regarding our paper describing the development of the HCVSTat instrument to assess treatment satisfaction in patients with chronic hepatitis C virus …”

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confidence: 99%

Commentary: the chronic hepatitis C virus treatment satisfaction (HCVTSat) instrument – authors’ reply

Szeinbach

Rocca

Littlefield

et al. 2013

Aliment Pharmacol Ther

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Hepatitis C-treated patients as a potential source for referral of new cases

Reygosa

Morales-Arráez

Hernández-Bustabad

et al. 2021

Gastroenterología y Hepatología (English Edition)

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Development and validation of the chronic hepatitis C virus treatment satisfaction (HCVTSat) instrument

Cited by 5 publications

References 36 publications

Commentary: the chronic hepatitis C virus treatment satisfaction (HCVTSat) instrument

Commentary: the chronic hepatitis C virus treatment satisfaction (HCVTSat) instrument

Commentary: the chronic hepatitis C virus treatment satisfaction (HCVTSat) instrument – authors’ reply

Hepatitis C-treated patients as a potential source for referral of new cases

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