Development and validation of the Frontal Fibrosing Alopecia Severity Score

Saceda‐Corralo, David; Moreno‐Arrones, Óscar M.; Fonda‐Pascual, Pablo; Pindado‐­Ortega, Cristina; Buendía-Castaño, Diego; Alegre-Sánchez, A.; Segurado‐Miravalles, Gonzalo; Rodrigues-Barata, Ana Rita; Jaén‐Olasolo, Pedro; Vañó‐Galván, Sergio

doi:10.1016/j.jaad.2017.09.034

Cited by 42 publications

(30 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lichen Planopilaris Activity Index score was notably low, especially among the male population (Table ). Currently, further disease activity scores have been specifically developed for patients with FFA such as the Frontal Fibrosing Alopecia Severity Index (FFASI) score and the Frontal Fibrosing Alopecia Severity Score (FFASS) . These scores include additional scoring for the extent of alopecia based on hairline recession and body area involvement and have however been criticized for being too complex (FFASI) and lacking trichoscopic evaluation of disease activity (FFASS) …”

Section: Discussionmentioning

confidence: 99%

Frontal fibrosing alopecia: demographic and clinical characteristics of 490 cases

Kanti

Constantinou

Reygagne

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

Background Frontal fibrosing alopecia (FFA) is a cicatricial alopecia mostly affecting the frontotemporal hairline. Its aetiology and associated factors remain unclear.Objective and methods An observational, cross-sectional and descriptive study was conducted in France and Germany to identify demographic and health characteristics associated with the severity of FFA. ResultsOf 490 included patients, 95% were female, of which 84% were postmenopausal. Age at onset of FFA symptoms ranged between 15 and 89 years, but diagnosis was frequently delayed up to 24 years. Lichen Planopilaris Activity Index scores were low (median 1.8, IQR 1.0 to 3.5). Thyroid function disorders were reported in 13% of men and 35% of women. Abnormal blood lipid levels were found in 42% of tested men and 47% of women. In the bivariate analyses, LPPAI scores were negatively correlated with abnormal testosterone (r s = À0.775) and oestrogen values (r s = À0.664), regular use of face cleaning products (r s = À0.465), hair colourants (r s = À0.679) and hairspray (r s = À0.500).Conclusions The most common comorbidity was thyroid disease, with proportions higher than in the European population, possibly reflecting a role of thyroid hormones in FFA pathogenesis. The association of abnormal testosterone and oestrogen values with lesser disease activity needs to be explored in further studies. Our correlation analyses do not support a role of leave-on cosmetic products in the pathophysiology of FFA.

show abstract

Section: Discussionmentioning

confidence: 99%

Frontal fibrosing alopecia: demographic and clinical characteristics of 490 cases

Kanti

Constantinou

Reygagne

et al. 2019

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…Thus, this score assessed for internal and external validity, comprehended less clinical parameters and lacked trichoscopic evaluation, important to improve the appraisal of inflammation. 32 In recent past, the trichoscopic visual scale demonstrated a strong correlation between severity of follicular hyperkeratosis at trichoscopy. 35…”

Section: Diagnosismentioning

confidence: 98%

“…31 However, soon was criticized based on its subjective features and the similarities with LPP exclusively in histology. 32 Then, the fibrosing alopecia severity index (FFASI) was proposed by Holmes at al including two major sections, A and B. FFASI-A employs clinical images of the hairline, divided into four sections. Alopecia severity is then ranked 1-5 based on hairline recession.…”

Section: Diagnosismentioning

confidence: 99%

Frontal fibrosing alopecia: state of the art and future directions

Lascasas

Peixoto

Vedor³

2020

Int J Res Dermatol

View full text Add to dashboard Cite

<p>Frontal fibrosing alopecia (FFA) is a primary lymphocytic cicatricial alopecia, characterized by recession of frontotemporal hairline with frequent involvement of eyebrows and affecting occasionally other body areas. Entitled an emerging epidemic, due to its rising incidence, FFA etiology remains unclear without proven effective therapies. This study reviews relevant publications on FFA, regarding pathogenesis, clinical findings, histology along with treatment and prognosis. A bibliographic search was conducted in the main international databases, using the term ‘FFA’. Guidelines, observational studies, randomized controlled trials, reviews, systematic reviews and meta-analysis regardless of publication date, presented in English, Portuguese or Spanish, were included in this review. 50 publications were fully analysed. The majority of FFA cases were observed in postmenopausal women, although both men and women from younger ages can be victims. From an etiological point of view, immune-mediated hypothesis is widely spread, as stem cells localized in the bulge region of the follicle are destroyed by an inflammatory infiltrate. However, environmental factors raised interest, since sunscreen use was related to a bigger incidence of FFA. Three clinical patterns have been described. Yet the failure to use standardized assessment methods in addition to the absence of prospective studies evaluating available therapies, do not concede comparable data. Spontaneous stabilization of disease can occur, but regrowth was only seen in scarce cases. Outcomes from randomized controlled trials and prospective studies are missing to draw further understanding of FFA.</p>

show abstract

“…The Frontal Fibrosing Alopecia Severity Index (FFASI) score developed by Holmes et al comprises measurement of hairline alopecia and notes the presence of hair loss elsewhere (face and body), plus other disease features including scalp LPP and facial papules [ 62 ]. The Frontal Fibrosing the Alopecia Severity Score (FFASS) proposed by Saceda-Corralo et al is based on the evaluation of severity and extent of frontal and temporal hairline recession, eyebrow loss, perifollicular erythema and hyperkeratosis, pruritus and pain associated with FFA [ 63 ].…”

Section: Diagnostics and Monitoringmentioning

confidence: 99%

Frontal fibrosing alopecia: a disease that remains enigmatic

Lis‐Święty

Brzeźińska-Wcisło

2020

pdia

View full text Add to dashboard Cite

Frontal fibrosing alopecia (FFA) is recognized to represent a generalized process of inflammatory scarring alopecia. Apart from the classic form affecting the frontal hairline, there are a range of disease manifestations involving loss of eyebrows and of eyelashes, loss of peripheral body hair, fibrosing alopecia in a pattern distribution, facial and extrafacial skin, mucous membrane, and nail involvement. Classic linear, diffuse "zigzag", pseudo "fringe sign", androgenetic alopecia-like, cockade-like, ophiasis-like and incomplete patterns are distinguished. The aetiology of FFA remains obscure, but a number of pathogenetic hypotheses and treatments to halt disease progression have been proposed.

show abstract

Development and validation of the Frontal Fibrosing Alopecia Severity Score

Cited by 42 publications

References 17 publications

Frontal fibrosing alopecia: demographic and clinical characteristics of 490 cases

Frontal fibrosing alopecia: demographic and clinical characteristics of 490 cases

Frontal fibrosing alopecia: state of the art and future directions

Frontal fibrosing alopecia: a disease that remains enigmatic

Contact Info

Product

Resources

About