Development and validation of the Mini Asthma Quality of Life Questionnaire

Abstract

The 32-item Asthma Quality of Life Questionnaire (AQLQ) has shown good responsiveness, reliability and construct validity; properties that are essential for use in clinical trials, clinical practice and surveys. However, to meet the needs of large clinical trials and long-term monitoring, where efficiency may take precedent over precision of measurement, the 15-item self-administered MiniAQLQ has been developed.The MiniAQLQ was tested in a 9-week observational study of 40 adults with symptomatic asthma. Patients completed the MiniAQLQ, the AQLQ, the Short Form (SF)-36, the Asthma Control Questionnaire and spirometry at baseline, 1, 5 and 9 weeks.In patients whose asthma was stable between clinic visits, reliability was very acceptable for the MiniAQLQ (intraclass correlation coefficient (ICC)=0.83), but not quite as good as for the AQLQ (ICC=0.95). Similarly, responsiveness in the MiniAQLQ (p=0.0007) was good but not quite so good as for the AQLQ (p<0.0001). Construct validity (correlation with other indices of health status) was strong for both the MiniAQLQ and the AQLQ. Criterion validity showed that there was no bias between the instruments (p=0.61) and the correlation between them was high (r=0.90).The Mini Asthma Quality of Life Questionnaire has good measurement properties but they are not quite as strong as those of the original Asthma Quality of Life Questionnaire. The choice of questionnaire should depend on the task at hand. Eur Respir J 1999; 14: 32±38.

Asthma Control Assessment Tools

“…Also, a higher ATAQ score (more control problems) was associated with lower quality of life in subjects with asthma, indicated by generic and diseasespecific quality of life measures, such as the SF-36, the standardized version of the Asthma Quality of Life Questionnaire, 12 and the Mini Asthma Quality of Life Questionnaire. 55,68 Furthermore, a strong correlation and similar performance were reported between the ATAQ and the ACT at home and in clinical settings (r ϭ Ϫ0.73). 25,69,70 …”

“…40 The ACQ has been validated for use as a self-administered tool in-person, at home, or by telephone. 40 Moderate to strong correlations resulted from comparing the ACQ with the AQLQ (r ϭ 0.76), 54 Mini Asthma Quality of Life Questionnaire (r ϭ 0.72 and 0.74), 55 the Medical Outcomes Survey Short Form-36 (SF-36) (r ϭ 0.19 -0.55), 56 and the ACT (r ϭ Ϫ0.82 to Ϫ0.89). 13,14,19 The correlations between the ACQ and the shortened versions were high (r ϭ 0.87 with ACQ-5, 0.98 with ACQ6a, and 0.92 with ACQ-6b).…”

Asthma outcomes improve with continuous positive airway pressure for obstructive sleep apnea

“…Objective complementary examinations for the diagnosis of GERD at follow‐up were not performed. Spanish‐validated versions of the Epworth Sleepiness Scale (ESS) 21, the Asthma Control Questionnaire (ACQ) 22, and the Mini Asthma Quality of Life Questionnaire (MiniAQLQ) 23 were used to assess daytime sleepiness, asthma control, and asthma‐related quality of life, respectively.…”

Assessing asthma control in routine clinical practice: use of the Royal College of Physicians ‘3 Questions’

“…the Asthma Control Questionnaire, (ACQ) 9 ) and asthma-related health status in adults (e.g. the Asthma Quality of Life Questionnaire, (AQLQ) 10 ) and in children (e.g. the Paediatric Caregivers Quality-of-life Questionnaire (PQLQ) 11 ) in the context of clinical trials, the usefulness of these tools in C o p y r i g h t G…”