Development and Validation of UV Spectroscopy Method for the Estimation of Dolutegravir in Bulk and Pharmaceutical Dosage Form

Dulange, Vaishnavi; Gajeli, G. B.

doi:10.52711/2231-5675.2021.00032

Cited by 5 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Climbazole's linearity was observed between 5-30 μg/ml, having a correlation coefficient of 0.9938. The linearity of Climbazole was depicted in Table 1 13 . Range: The linearity has been observed in the 5-30 μg/ml range.…”

Section: Resultsmentioning

confidence: 99%

Untitled

2023

IJPSR

View full text Add to dashboard Cite

Climbazole is a topical antifungal agent commonly used to treat human fungal skin infections such as dandruff and eczema. The goal of research work was to develop and validate a simple, precise, quick, and highly efficient UV spectrophotometric approach for quantifying Climbazole in bulk and shampoo dosage form. The quantification was completed using a twin beam UV spectrophotometer at 222 nm and ethanol (99.9%) as the solvent for the estimate. The Climbazole calibration curve exhibit strong correlation coefficient (R 2 =0.9938) and high linearity in the range of 5-25 µg/ml concentrations. The accuracy was found to be between 98.21%-99.83%. The accuracy of the approach was proved by the percent relative standard deviation being less than 2.0%. It was observed that the intraday and interday precision found within acceptable ranges. The method's sensitivity was assessed using the detection limit and quantification limit, which were discovered to be 2.37 µg/ml and 7.20 µg/ml, respectively. In this paper, we introduce a UV-spectrophotometric technique for investigating Climbazole using ethanol as solvent. The suggested method demonstrated excellent selectivity, specificity, and linearity in accordance with ICH Q2 (R1) requirements. Also, marketed pharmaceutical formulations were used to show the developed approach's efficiency and a high recovery rate. It is obvious that the suggested method will serve as a normative approach for the regular testing of Climbazole in pharmaceutical formulations and bulk dosage forms.

show abstract

Section: Resultsmentioning

confidence: 99%

Untitled

2023

IJPSR

View full text Add to dashboard Cite

show abstract

“…Many UV spectrophotometric methods are reported for other drugs in literature. [8][9][10][11][12][13][14][15][16][17][18][19]…”

mentioning

confidence: 99%

Validated First-Order Derivative Ultraviolet Spectrophotometric Determination of Rebamipide in Pharmaceutical Products

S R,

et al. 2023

IJPQA

View full text Add to dashboard Cite

A very simple, accurate, precise, and reproducible process has been established for the estimation of rebamipide in pharmaceuticals. The literature review suggested that no UV method for quantitative estimation of first-order derivative for the rebamipide, accordingly a method has been developed and reported. As per the need for design a novel approach to analyze the drug utilizing dimethyl formamide as a solvent was identified. Rebamipide has absorbance maxima for first order derivative 314 nm. Rebamipide drug follows Beer’s law in a range of concentration between 20 to 200 μg/mL. The recovery studies verified the proposed method’s accuracy and findings were validated in accordance with ICH recommendations. The findings were deemed to be reliable and satisfactory. As a result, the suggested method can be used to quantitatively estimate Rebamipide in ordinary analysis work

show abstract

Quantification of Vortioxetine in Pharmaceutical preparations by validated area under curve UV Spectrophotometric Analytical method

Karajgi,

Angadi,

Potadar

2023

RJPT

View full text Add to dashboard Cite

To carry out the single component analysis of Vortioxetine Hydrochloride pharmaceutical formulated preparations, avery simple, highly accurate, satisfactorily precise, and reproducible technique is proposed for Quantitative determination of Vortioxetine drug. Areaunder Curve Method is considered because no UV approaches not been described so far, it was noted that a differenttactic for analysis of the drug using methanol as a solvent tried. Vortioxetine hydrochloride has maximum absorbance at 230nm and the analysis was carried out in the area between 220nm and 240nm. The proposed method's accuracy was set by carrying recovery studies, and the outcomes were authenticated in accord with ICH recommendations. The endings were established to be agreeable and repeatable. Thus the offered technique can be effectively useful for the quantification analysis of the drug Vortioxetine hydrochloride.

show abstract

Development and Validation of UV Spectroscopy Method for the Estimation of Dolutegravir in Bulk and Pharmaceutical Dosage Form

Cited by 5 publications

References 1 publication

Untitled

Untitled

Validated First-Order Derivative Ultraviolet Spectrophotometric Determination of Rebamipide in Pharmaceutical Products

Quantification of Vortioxetine in Pharmaceutical preparations by validated area under curve UV Spectrophotometric Analytical method

Contact Info

Product

Resources

About