Development and Verification of a novel cuproptosis- and immune-associated based prognostic genetic signature for pancreatic ductal adenocarcinoma

Xu, Xiang; Liang, Jia-Hua; Xu, Qiong‐Cong; Yin, Xiao‐Yu

doi:10.1016/j.clinre.2023.102089

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2024

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Cited by 2 publications

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In-silico analysis of islet amyloid polypeptide (IAPP) to predict the potential mutations involved in type II diabetes

Viswateja Reddy,

Ramalingam

2024

AIP Conference Proceedings

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In-silico analysis of islet amyloid polypeptide (IAPP) to predict the potential mutations involved in type II diabetes

Viswateja Reddy,

Ramalingam

2024

AIP Conference Proceedings

View full text Add to dashboard Cite

Copper homeostasis and copper-induced cell death in tumor immunity: implications for therapeutic strategies in cancer immunotherapy

Zhang,

Huang,

et al. 2024

Biomark Res

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Copper is an important trace element for maintaining key biological functions such as cellular respiration, nerve conduction, and antioxidant defense. Maintaining copper homeostasis is critical for human health, and its imbalance has been linked to various diseases, especially cancer. Cuproptosis, a novel mechanism of copper-induced cell death, provides new therapeutic opportunities for metal ion regulation to interact with cell fate. This review provides insights into the complex mechanisms of copper metabolism, the molecular basis of cuproptosis, and its association with cancer development. We assess the role of cuproptosis-related genes (CRGs) associated with tumorigenesis, their importance as prognostic indicators and therapeutic targets, and the impact of copper homeostasis on the tumor microenvironment (TME) and immune response. Ultimately, this review highlights the complex interplay between copper, cuproptosis, and cancer immunotherapy.

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Development and Verification of a novel cuproptosis- and immune-associated based prognostic genetic signature for pancreatic ductal adenocarcinoma

Cited by 2 publications

References 35 publications

In-silico analysis of islet amyloid polypeptide (IAPP) to predict the potential mutations involved in type II diabetes

In-silico analysis of islet amyloid polypeptide (IAPP) to predict the potential mutations involved in type II diabetes

Copper homeostasis and copper-induced cell death in tumor immunity: implications for therapeutic strategies in cancer immunotherapy

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