Development and verification of saphenous, tibial and common peroneal nerve block techniques for analgesia below the thigh in the nonchondrodystrophoid dog

Rasmussen, Lara M; Lipowitz, Alan J.; Graham, Lori

doi:10.1111/j.1467-2995.2005.00234.x

Cited by 26 publications

(25 citation statements)

References 75 publications

(63 reference statements)

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“…A previous study evaluating the radial, ulnar, median and musculocutaneous nerve blocks showed greater successful staining of the nerves in cadavers compared to the clinical success rates on live dogs (Trumpatori et al 2010). This was also observed in two studies of the pelvic limbs in dogs, which showed that successful staining of nerves at post-mortem did not correspond to clinical efficacy (Rasmussen et al 2006a and2006b). …”

Section: Discussionmentioning

confidence: 54%

Comparison of three techniques for paravertebral brachial plexus blockade in dogs

Rioja

Sinclair

Chalmers

et al. 2012

Veterinary Anaesthesia and Analgesia

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Objective To compare success and complication rates, based on staining of nerves and other structures, among three techniques of paravertebral brachial plexus blockade (PBPB) in dogs. Study design Prospective randomized design.Animals A total of 68 thoracic limbs from 34 dogs. Methods ResultsThe median (range) number of nerves stained was 2 (0-4) with BL, 1 (0-3) with NS and 1 (0-4) with US guided technique. No significant differences in staining of C6, C8 and T1 or other structures were found among techniques. Nerve C7 was more likely to be stained by BL (p=0.05). Time to perform the blocks was significantly different among techniques, with mean ± SD duration in minutes of 3.6 ± 1.8 with BL, 6.3 ± 2.7 with US and 12.2 ± 5 with NS. The most common complication was staining of the spinal cord (29%, 38% and 39% with BL, NS and US, respectively).Conclusions Success rates were low and complication rates were relatively high, based on staining, with the three techniques.Clinical relevance The use of more advanced techniques for PBPB in dogs is not justified according to this study. Clinical significance of the complications encountered in this study should be evaluated.

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Section: Discussionmentioning

confidence: 54%

Comparison of three techniques for paravertebral brachial plexus blockade in dogs

Rioja

Sinclair

Chalmers

et al. 2012

Veterinary Anaesthesia and Analgesia

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“…This dose of bupivacaine is not sufficient to cause neuronal degeneration, given the exposure time and injection method (Foster and Carlson, 1980). The method of injection is an adaptation previously described in dog where a perineural injection of bupivacaine was applied to the saphenous, tibial and common peroneal nerves for analgesia below the thigh (Rasmussen et al, 2006), the injection sites were adjusted for use in rats. The four experimental groups were as follows: saline perineural pre-injection with saline injected into the paw (saline control); saline perineural preinjection with λ-carrageenan injected into the paw (CIP group); bupivacaine perineural preinjection with saline injected into the paw (nociceptive inhibition control); bupivacaine perineural pre-injection, with λ-carrageenan injected into the paw (nociception inhibited CIP group).…”

Section: Discussionmentioning

confidence: 99%

Nociceptive inhibition prevents inflammatory pain induced changes in the blood–brain barrier

et al. 2008

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Previous studies by our group have shown that peripheral inflammatory insult, using the λ-carrageenan inflammatory pain (CIP) model, induced alterations in the molecular and functional properties of the blood-brain barrier (BBB). The question remained whether these changes were mediated via an inflammatory and/or neuronal mechanism. In this study, we investigated the involvement of neuronal input from pain activity on alterations in BBB integrity by peripheral inhibition of nociceptive input. A perineural injection of 0.75% bupivacaine into the right hind leg prior to CIP was used for peripheral nerve block. Upon nerve block, there was a significant decrease in thermal allodynia induced by CIP, but no effect on edema formation 1 h post CIP. BBB permeability was increased 1 h post CIP treatment as determined by in situ brain perfusion of [ 14 C] sucrose; bupivacaine nerve block of CIP caused an attenuation of [ 14 C] sucrose permeability, back to saline control levels. Paralleling the changes in [ 14 C] sucrose permeability, we also report increased expression of three tight junction (TJ) proteins, zonula occluden-1 (ZO-1), occludin and claudin-5 with CIP. Upon bupivacaine nerve block, changes in expression were prevented. These data show that the λ-carrageenan induced changes in [ 14 C] sucrose permeability and protein expression of ZO-1, occludin and claudin-5 are prevented with inhibition of nociceptive input. Therefore, we suggest that nociceptive signaling is in part responsible for the alteration in BBB integrity under CIP.

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“…This study was approved by the University of Minnesota Animal Care and Use Committee and written, informed client consent was obtained for each patient. Chondrodystrophoid dogs were excluded because of the poor technical success of the injection protocol in these breeds (Rasmussen et al. in press).…”

Section: Methodsmentioning

confidence: 99%

“…Bupivacaine 0.4 mL kg −1 (Sensorcaine 0.5%; Astra USA, Inc., Westborough, MA, USA) or sterile, preservative‐free saline (equivalent volume) was administered (Fig. 1) (Rasmussen et al. in press) to the study leg by one investigator (LFG) unaware of the study group designation.…”

Section: Methodsmentioning

confidence: 99%

Controlled, clinical trial assessing saphenous, tibial and common peroneal nerve blocks for the control of perioperative pain following femoro-tibial joint surgery in the nonchondrodystrophoid dog

Rasmussen

Lipowitz

Graham

2006

Veterinary Anaesthesia and Analgesia

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Development and verification of saphenous, tibial and common peroneal nerve block techniques for analgesia below the thigh in the nonchondrodystrophoid dog

Cited by 26 publications

References 75 publications

Comparison of three techniques for paravertebral brachial plexus blockade in dogs

Comparison of three techniques for paravertebral brachial plexus blockade in dogs

Nociceptive inhibition prevents inflammatory pain induced changes in the blood–brain barrier

Controlled, clinical trial assessing saphenous, tibial and common peroneal nerve blocks for the control of perioperative pain following femoro-tibial joint surgery in the nonchondrodystrophoid dog

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