Development and Vlaidation of Simple Uv-Spectrophotometric Method of Quantization of Diazepam in Bulk Drug and Solid Dosage Formulation Using Mixed Solvency Concept

Jain, Sanjay; Maheshwari, R. K.; Nema, Rajesh Kumar; Singhvi, Indrajeet

doi:10.22159/ijcpr.2017v9i6.23421

Cited by 9 publications

(7 citation statements)

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“…The mixed solvency approach has been used to study a wide variety of medications for solubility enhancement. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]…”

Section: Mixed Solvency Conceptmentioning

confidence: 99%

Untitled

2023

AJP

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Introduction:In recent generation, the difficult task is to overcome solubility problems in the formulation development of the drug. The lower water solubility of drugs causes various challenges in developing formulations and the use of harmful organic solvents produces toxicity. So, this problem is overcome by the mixed solvency concept proposed by Dr R.K. Maheshwari in 2009. In this work, amlodipine besylate was chosen as a model drug and solubilizers selected were sodium benzoate, sodium acetate, sodium citrate, sodium caprylate, poloxamer 407, l-lysine, β-cyclodextrins and niacinamide. The solid dispersions are proposed to be formulated using these expectedly safe water-soluble additives as per mixed solvency concept. Materials and Methods: Solid dispersions were prepared using solvent evaporation method, amlodipine besylate was chosen as a model drug and solubilizers selected were sodium benzoate, sodium acetate, sodium citrate, sodium caprylate, poloxamer 407, l-lysine, β-cyclodextrins and niacinamide. The amlodipine besylate used for the preparation of solid dispersion was characterized and identified by UV spectrophotometric analysis, melting range determination and comparative dissolution studies. Results and Discussions: The amlodipine besylate used for the preparation of solid dispersion was characterized and identified by UV spectrophotometric analysis and melting range determination. The observed values were in accordance with the reported values in the literatures. For pre-formulation studies, the solubility studies of the drug were done in different blends. Also, calibration curves in water and 0.1N HCl were prepared. Interaction studies of drug-solubilizers have shown no interaction and incompatibility between drugs and solubilizers. Solubility of amlodipine besylate drug sample was reported in different blends. UV spectrophotometric study of drugs and solubilizers indicated no drug-solubilizer interference at 368 nm. Different blends of solubilizers were prepared by varying their concentrations. Out of these prepared blends, blend V, blend O and blend C were selected on the basis of the drug solubility at 80-90. Different solid dispersions were prepared with different drug and solubilizers ratios. One of three trail batches of solid dispersions were selected for comparative dissolution studies. The formulated solid dispersions were compared with marketed tablet (tablet powder) and pure drug. Summary and Conclusion: The main objective of the present study is to explore the concept of mixed solvency to formulate the solid dispersion of model drug, amlodipine besylate and also to propose mixed solvency concept as a tool to overcome the situation of limiting resources to increase solubility of poorly soluble substances. The drug content and drug release studies were assessed. Based on the above findings, it may be concluded that the solubility and release of a poorly water-soluble drug can be enhanced using various

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“…The mixed solvency approach has been used to study a wide variety of medications for solubility enhancement. [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]…”

Section: Mixed Solvency Conceptmentioning

confidence: 99%

Untitled

2023

AJP

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“…The withdrawn samples were replaced with equal volumes of the release medium kept at 37 °C. All experiments were conducted in triplicate [20]. The data acquired from the release studies were analyzed kinetically using various mathematical models including zero-order, first-order, and Higuchi models [21,22].…”

Section: In Vitro Drug Release Studiesmentioning

confidence: 99%

Effect of Different Formulation Variables on Release Characteristics of Gastro-Floating Microspheres of Ethyl Cellulose/Carbopol 934p Encapsulating Sorafenib

Ahmed

2019

Int J Pharm Pharm Sci

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Objective: The aim of this study is to prepare floating hollow microspheres encapsulating Sorafenib (SFN) to enhance its oral bioavailability. Methods: Gastro-floating hollow adhesive microspheres containing SFN were produced by using an emulsion solvent evaporation technique with ether and ethanol as solvents. Ethyl cellulose and carbopol 934P were used as the encapsulating carriers. The effects of formulation parameters like, solvent volume ratio, and drug to polymer ratio (D: P ratio), encapsulation eﬃciency percentage EE%, floating percentage, and release of SFN after 12 h (Rel12) were investigated and analyzed using a (32) full factorial design. Results: The floating percentage of the microspheres was found to be 76.5%. The in vitro drug release from these hollow microspheres followed the Higuchi model equation. The in vivo results showed that approximately 1.96-fold improvement in the relative bioavailability of the microspheres compared with that of the commercial tablet. Conclusion: The results demonstrate that the hollow microspheres with good gastro-floating ability are a promising delivery system to enhance SFN bioavailability.

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“…Hydrotropic agents, such as urea, sodium benzoate, sodium citrate, sodium acetate, sodium caprylate, and others, can easily increase the solubility of a drug. [27][28][29][30] In this study, we increased the solubility of norfloxacin using mixed hydrotropic techniques. Mixed hydrotropic techniques require two or more hydrotropic agents.…”

Section: Introductionmentioning

confidence: 99%

“…Hydrotropic agents, such as urea, sodium benzoate, sodium citrate, sodium acetate, sodium caprylate, and others, can easily increase the solubility of a drug. 27 28 29 30…”

Section: Introductionmentioning

confidence: 99%

“…Hydrotropic agents are ionic organic salts that help to increase the solubility of any solute substance. 24 25 26 These hydrotropic agents are less expansive and readily available as compared with organic solvents and have no harmful effects. Hydrotropic agents, such as urea, sodium benzoate, sodium citrate, sodium acetate, sodium caprylate, and others, can easily increase the solubility of a drug.…”

Section: Introductionmentioning

confidence: 99%

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Eco-friendly and Economical Spectrophotometric Estimation of the Low Water-Soluble Drug (Norfloxacin) Applying the Concept of Mixed Hydrotropy

Soni

Sharma

2021

Journal of Health and Allied Sciences NU

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Objectives The main aim of the research was to analyze an economical and eco-friendly approach to improve the solubility of norfloxacin. The current analysis was to utilize the hydrotropic solutions to extract the drugs from their dosage forms, avoiding the use of costlier and harmful organic solvents. Materials and Methods In this study, an ultraviolet–visible spectrophotometer (model 1800, Shimadzu Corporation) was used to analyze the norfloxacin drug. The mixed hydrotropy approach was used to determine the solubility of norfloxacin. In this work, a blend solution (20% of urea + 20% of sodium benzoate) was used as a hydrotropic solubilizing agent. Results The solubility of norfloxacin drug in water was very low at ∼0.88 mg/mL and the solubility of norfloxacin drug in the blend solution was 11 mg/mL. From 98.96 (tablet II) to 99.35 (tablet I), the percent estimation value was achieved. This value was nearly 100, so the proposed method was correct. Standard deviation (0.2540–0.4156), percentage coefficient of variation (0.2566–0.4183), and the value of standard error (0.1481–0.2415) are also very low; hence, we can say that the proposed method is accurate. Conclusion To avoid the use of organic solvents, the mixed hydrotropy concept can be used for spectrophotometric estimation of low water-soluble drugs from bulk drug samples. It provides an economical and environmentally friendly mechanism.

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Development and Vlaidation of Simple Uv-Spectrophotometric Method of Quantization of Diazepam in Bulk Drug and Solid Dosage Formulation Using Mixed Solvency Concept

Cited by 9 publications

References 1 publication

Untitled

Untitled

Effect of Different Formulation Variables on Release Characteristics of Gastro-Floating Microspheres of Ethyl Cellulose/Carbopol 934p Encapsulating Sorafenib

Eco-friendly and Economical Spectrophotometric Estimation of the Low Water-Soluble Drug (Norfloxacin) Applying the Concept of Mixed Hydrotropy

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