Development, characterization and antimalarial efficacy of dihydroartemisinin loaded solid lipid nanoparticles

Encapsulation of Ibuprofen Into Solid Lipid Nanoparticles for Controlled and Sustained Release Using Emulsification Solvent Evaporation Technique

“…From the results obtained, the formulation with an internal to the external ratio of 1:1 comparatively gave the largest particle sizes with a non-uniform particle distribution (PDI=0.304). The PDI values are expected to be generally low (0.001-0.290) for a homogeneous system [19]. The higher values of PDI are an indication of a very wide distribution of particle sizes, and this is also evident from the nature of the graph obtained from the PCS analysis ( Fig.…”

“…High values of zeta potential correlate with a lesser tendency to aggregate or flocculate and are indicative colloidal stability of the nanoformulation [21]. Studies have reported that electrostatically stable nanoformulations should have a minimum zeta potential of ±30 [10,19]. It is evident from the results given in Table 2 that all the prepared formulations showed good stability as seen from the high values of zeta potential.…”

“…of poorly water-soluble drugs [16][17][18]. This encapsulation is what leads to the formation of the solid lipid nanoparticles (SLNs) which are submicron colloidal drug carriers composed of lipids or waxes dispersed in an aqueous surfactant solution [17,19,20].…”

“…The nanoparticle drug carriers were prepared by the method described by Omwoyo et al, [17,19] with slight modifications. Nanoparticle drug carriers for IBU were prepared using a modified emulsification solvent evaporation technique.…”

“…4) which indicates the existence of an amorphous state of the nanoparticles as compared to the crystalline nature of the drug. This is attributed to the incorporation of IBU into the lipid matrix and successful encapsulation of the drug inside the excipients [18,19,25].…”