Development, evaluation, and optimization of flurbiprofen nanoemulsions gel using quality by design concept

Abstract

T he objective of this study was to formulate topical gel loaded nanoemulsions containing flurbiprofen using volatile oil.The gel released the drug at a controlled rate to the targeted site. Flurbiprofen (log P = 4.09) in generally used for transdermal treatment of rheumatoid arthritis and osteoarthritis. Selection of the oil phase, surfactant, and cosurfactant was done by individual screening method with the aid of pseudo-ternary phase study. International Conference on Harmonisation Q8 guidelines was applied using 3 2 factorial designs coupled with response surface methodology. The formulations were prepared by using spontaneous emulsification method. The selected formulation from various statistical and other studies was investigated. It was found that selected formulation showed an optimum in-vitro data. Later the optimized formulation obtained within the tentative design space was incorporated in the gel and compared with the marketed formulation. The result suggested the optimized formulation with good potential for transdermal delivery of the drug than the marketed formulations.

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“…The formulations were created using a procedure called spontaneous emulsification. The outcome pointed to the improved formulation as having greater potential for transdermal medication administration than the commercial formulations 34 .…”

New Approach for Administration of Doxazosin Mesylate: Comparative Study between Liquid and Solid Self-nanoemulsifying Drug Delivery Systems

“…Different samples of pure components as well as selected liquid and solid SNEDDS were examined at a wave number range 4000-400 cm −1 using FTIR (Perkin-Elmer 1600 FTIR Spectrophotometer, Norwalk, USA) by KBr disc method at a resolution of 4 cm −1 (Aiswarya et al, 2015).…”

Formulation and Evaluation of Chlorothalidone Loaded Mouth Dissolving Film-a Bioavailability Enhancement Approach Using Multilevel Categoric Design

“…The dependent variables or response evaluated were % drug release, disintegration time in second and folding endurance, etc. The total 9 trials were generated by Design-Expert ® 12 software; the experimental data were analyzed using analysis of variance (ANOVA) by fitting responses in the respective run [5]. 9 ml 9 ml 9 ml 9 ml 9 ml 9 ml 9 ml 9 ml 9 ml Methanol 1 ml 1 ml 1 ml 1 ml 1 ml 1 ml 1 ml 1 ml 1 ml…”

“…Chlorthalidone showed maximum absorption at wavelength 275.8 nm in 6.8 pH phosphate buffer. A standard curve was plotted by taking absorption of diluted stock solutions (5,10,15,20,25 and 30 μg/ml) at wavelength 275.8 nm [18].…”