Development, formulation, and characterization of an adapalene-loaded solid lipid microparticle dispersion for follicular penetration

Stability and In Vitro Skin Compatibility of an Adapalene-Loaded Solid Lipid Microparticle Dispersion

“…1), and the T onset of about 55°C and T recryst of approximately 28°C were nearly the same over 12 weeks (Table 1). Compared to that, a slight increase of the particle size from about 3.7 µm to 4.3 µm was detected at 23°C over 12 weeks which is in accordance with a previous report [1]. The same applies for the thermoanalytical data with a T onset of approximately 56°C and a T recryst of about 28°C after 12 weeks.…”

“…A novel adapalene-loaded solid lipid microparticle (SLMA) dispersion composed of 13.93% hydrogenated palm oil, 5.97% purified lecithin, 0.1% adapalene, 12% poloxamer 407 (P407), 3% polyethylene glycol 12000, 0.2% potassium sorbate, 0.1% citric acid, and 64.7% water of double-distilled grade (all by weight) featured follicular penetration, erosion in sebum lipids and a superior drug release in sebum compared to the commercial cream formulation Differin ® [1,2]. Further convenient attributes are the physical and chemical stability regarding particle size, melting behavior, and drug content at ambient storage conditions, and the utilization of safe inactive ingredients for dermal application.…”

Solid lipid microparticles as an approach to drug delivery

“…No significant difference in drug permeation was observed between LMs and LNs, suggesting no sizedependent effect in the examined dimensional range. LMs (mean particle size, 4.2 µm) containing a model retinoid drug were developed by Lauterbach and Mueller-Goymann [102] for the delivery of the active ingredient to the hair follicle. In vitro studies with porcine ear skin confirmed the follicular penetration and dissolution of the particles in sebum.…”

Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: potential tool for the treatment of androgenic alopecia

“…It is obvious that, the success of this strategy would be dependent on a suitable carrier which could improve skin accumulation and reduce percutaneous drug absorption 4,9 . Small particles are increasingly being implemented in dermatological and cosmetic products that are applied to the skin. In later years, micro and nanoemulsions, low-molecular weight dextrans, microspheres and niosomes or liposomes were frequently applied in cosmetic products to improve their penetration into the skin [10][11][12][13][14] . Solid lipid nanoparticles (SLNs) have recently attracted much attention as a novel colloidal drug vehicle due to their numerous advantages over other carriers intended for dermal drug delivery.…”

“…In spite of the advantages of SLNs, their low capacity to carry the drugs especially hydrophilic ones, their limitation to be used for topical application of high dose medicines such as antibiotics, and their high cost for industrial scale up must be considered. The role and importance of SLNs in dermal drug delivery are recently reported by a limited number of comprehensive review articles 13,[32][33][34] .…”