Development of 1,3-diynyl derivatives of noscapine as potent tubulin binding anticancer agents for the management of breast cancer

Meher, Rajesh Kumar; Pragyandipta, Pratyush; Reddy, Priyanka; Pedaparti, Ravikumar; Kantevari, Srinivas; Naik, Pradeep Kumar

doi:10.1080/07391102.2021.1982008

Cited by 10 publications

(7 citation statements)

References 61 publications

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“…Previous studies have also shown that Noscapine has no cytotoxic effect on normal human embryonic kidney cells (293 T) that is <5%, even at 100 µM (Meher et al 2022). Our study examined cytotoxic effects on human red blood cells (RBCs) and in murine macrophage cell lines (J774.A.1), showing no or very little cytotoxicity (Fig.…”

Section: Discussionmentioning

confidence: 90%

In vitro and in vivo evaluation of Noscapine as a potential antimalarial vis-à-vis standard Dihydroartemisinin (DHA) against Plasmodium falciparum 3D7, P. falciparum clinical isolate Pf140/SS and P. berghei ANKA

Babu,

Maharana,

Chhatria

et al. 2023

Preprint

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Malaria is a global public health menace. The quest for new antimalarials and adjuvants for malaria in the backdrop of artemisinin resistance has been enormous. This study evaluates the comprehensive antimalarial activity of the natural phytochemical compound Noscapine, against Plasmodium falciparum 3D7 strain (Pf3D7), clinical isolate (Pf140/SS) and in Plasmodium berghei ANKA (PbA), inhibiting in vitro and in vivo parasite growth under controlled conditions as evaluated through the ring-stage survival assay, phenotypic assessments and SYBR-green based fluorescence assay. Cytotoxicity of Noscapine was evaluated against the J774. A.1 murine macrophage cell line besides profiling its hemolysis activities against human RBCs. The antimalarial efficacy of Noscapine against Pf3D7 and Pf140/SS was similar or better than standard antimalarial Dihydroartemisinin (DHA), with the IC50 value of 7.68±0.88 and 5.57±0.74 nM/mL respectively along with more than 95% inhibition in infected Wister albino rats with PbA after 4-day suppressive test. Importantly, unlike DHA, no toxicity symptoms were observed with CC50 value 1748 nM/mL or hemolysis with Nospcapine, even at extremely high concentrations. Based on the published literature as on date, this is the first report on native Noscapine, which has shown potent antimalarial efficacy and safety profiles vis-à-vis standard antimalarial DHA, demonstrated through in vitro and in vivo models of animal and clinical malaria parasites.

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Section: Discussionmentioning

confidence: 90%

In vitro and in vivo evaluation of Noscapine as a potential antimalarial vis-à-vis standard Dihydroartemisinin (DHA) against Plasmodium falciparum 3D7, P. falciparum clinical isolate Pf140/SS and P. berghei ANKA

Babu,

Maharana,

Chhatria

et al. 2023

Preprint

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“…Several groups of the most potent derivatives have been designed, synthesized, and experimentally evaluated for their therapeutic efficacy against multiple cancer cell lines to resolve the issue. [97][98][99][100][101][102]…”

Section: Curcuminmentioning

confidence: 99%

Natural therapeutics for cancer treatment: success, challenges, and prospect

Dubey,

Rath,

Meher

et al. 2023

J Bio-X Res

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Cancer is a terrifying disease that has become one of the world’s most challenging health concerns, necessitating a proactive approach to its treatment. Nature is a rich source of new chemical entities and a promising avenue for cancer research. Because of their different modes of action on target events in many ways, nature-derived chemicals are considered good possibilities for anticancer drug development. The current review article highlights recent breakthroughs in cancer therapeutics, including natural therapeutic molecules and their mechanisms of action against cancer treatment, as well as their limits, challenges, and prospect. For the review, article data have been collected from previously studied and published research reports, clinical evaluations, case studies, and clinical statistical data generated by scientific research organizations of repute. The chemical structures have been drawn using computational software (chemsketch). The development of promising candidates that can prevent or reduce the proliferation of cancer cells without causing adverse effects from these therapeutics is now underway. Further, nature-derived products are a game-changer because they are simple, safer, environmentally friendly, low-cost, quick, and less toxic than traditional treatment techniques. However, many bioactive chemicals and their analogs have been discovered as possible anticancer treatment options. In the review, the potent therapeutics phytochemicals derived from nature with their tremendous anticancer effects with limitations and prospects have been studied and analyzed based on previously published articles and reports.

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“…Apoptotic cells were identified based on stains taken by the cells. The cells stained with red represent both live and pre-apoptotic cells which are stained with EtBr displayed membrane blabbing forming apoptotic bodies as well as nuclear condensation [47].…”

Section: Ethidium Bromide For Detection Of Apoptosismentioning

confidence: 99%

Antimicrobial, anticancer, and antioxidant potential of two dominant macro-lichen Dirinaria aegialita and Parmotrema praesorediosum collected from Similipal Biosphere Reserve of Odisha, India

Pradhan¹,

Upreti²,

Meher³

et al. 2022

J App Biol biotech

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The present study was undertaken to evaluate the antimicrobial, antioxidant, and anticancer activity of Dirinaria aegialita (Afzel. ex Ach.) B.J. Moore and Parmotrema praesorediosum (Nyl.) Hale, the two dominant macrolichens taxa from the Similipal Biosphere Reserve of Odisha. Both the lichens were evaluated for their efficacy against three bacterial species such as Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtilis, and three fungal species such as Aspergillus niger, Trichoderma harzianum, and Candida albicans. The D. aegialita and P. praesorediosum showed higher inhibitory effect against Bacillus subtilis and Staphylococcus aureus, respectively. D. aegialita also showed the higher inhibitory activity against MCF-7 and MDA MB-231 breast cancer cell line as compared to P. praesorediosum. Besides, D. aegialita was found to have better antioxidant activity than P. praesorediosum in scavenging assay. Thus, the results of the above study confirmed that D. aegialita species is having better potential in its antibacterial, antioxidant, and anticancer activity as compared to P. praesorediosum.

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Development of 1,3-diynyl derivatives of noscapine as potent tubulin binding anticancer agents for the management of breast cancer

Cited by 10 publications

References 61 publications

In vitro and in vivo evaluation of Noscapine as a potential antimalarial vis-à-vis standard Dihydroartemisinin (DHA) against Plasmodium falciparum 3D7, P. falciparum clinical isolate Pf140/SS and P. berghei ANKA

In vitro and in vivo evaluation of Noscapine as a potential antimalarial vis-à-vis standard Dihydroartemisinin (DHA) against Plasmodium falciparum 3D7, P. falciparum clinical isolate Pf140/SS and P. berghei ANKA

Natural therapeutics for cancer treatment: success, challenges, and prospect

Antimicrobial, anticancer, and antioxidant potential of two dominant macro-lichen Dirinaria aegialita and Parmotrema praesorediosum collected from Similipal Biosphere Reserve of Odisha, India

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