Development of 1 Month Sustained-Release Microspheres Containing Liraglutide for Type 2 Diabetes Treatment
Zejing Gao,
Yi Wei,
Jia Ge
et al.
Abstract:Liraglutide has been extensively applied in the treatment of type 2 diabetes mellitus (T2DM), but its 11−15 h half-life resulted in daily administration, which led to poor patient compliance. This study aimed to solve this problem by developing liraglutide-loaded microspheres with a 1 month sustained release prepared by the W 1 /O/W 2 method combined with the premix membrane emulsification technique to improve therapeutic efficacy. Remarkably, we found that the amphiphilic properties of liraglutide successfull… Show more
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