2023
DOI: 10.1021/acschemneuro.3c00658
|View full text |Cite
|
Sign up to set email alerts
|

Development of 2-Aminotetralin-Type Serotonin 5-HT1 Agonists: Molecular Determinants for Selective Binding and Signaling at 5-HT1A, 5-HT1B, 5-HT1D, and 5-HT1F Receptors

Ryan P. McGlynn,
Meng Cui,
Brittany Brems
et al.

Abstract: The serotonin (5-hydroxytryptamine, 5-HT) 5-HT 1 G-protein coupled receptor subtypes (5-HT 1A/1B/1D/1E/1F ) share a high sequence homology, confounding development of subtype-specific ligands. This study used a 5-HT 1 structure-based ligand design approach to develop subtype-selective ligands using a 5-substituted-2-aminotetralin (5-SAT) chemotype, leveraging results from pharmacological, molecular modeling, and mutagenesis studies to delineate molecular determinants for 5-SAT binding and function at 5-HT 1 su… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 57 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?