Development of 3D in Vitro Technology for Medical Applications

Ou, Keng Liang; Hosseinkhani, Hossein

doi:10.3390/ijms151017938

Cited by 88 publications

(51 citation statements)

References 73 publications

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“…cell supports, is to mimic the function of extracellular matrix (ECM) which not only provides an appropriate mechanical environment for cells, but also supplies signals that direct cell attachment, proliferation, differentiation and metabolism. The choice of biomaterials and the selection of experimental conditions for design of these scaffolds are essential parameters in assuring the appropriate setting for cells to grow and proliferate within these 3D matrices (O'Brien, 2011;Ou & Hosseinkhani, 2014).…”

Section: Introductionmentioning

confidence: 99%

Tailoring chitosan/collagen scaffolds for tissue engineering: Effect of composition and different crosslinking agents on scaffold properties

Martinez

Blanco

Davidenko

et al. 2015

Carbohydrate Polymers

123

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Section: Introductionmentioning

confidence: 99%

Tailoring chitosan/collagen scaffolds for tissue engineering: Effect of composition and different crosslinking agents on scaffold properties

Martinez

Blanco

Davidenko

et al. 2015

Carbohydrate Polymers

123

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“…It has been reported that polymers modified with amino acids or peptides could afford anti-fouling properties with decreased protein adsorption and platelet deposition. [16] Other studies have also demonstrated that the biocompatibility of peptides was highly valuable for preparation of materials for regenerative medicines [17,18] and bone regeneration scaffolds. [19] However, such modifications have been realized mostly through lengthy processes involving chemical reactions.…”

Section: Introductionmentioning

confidence: 98%

One-step surface modification of polyurethane using affinity binding peptides for enhanced fouling resistance

Wang

Zhang

et al. 2015

Journal of Biomaterials Science, Polymer Edition

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Affinity binding peptides were examined for surface fabrication of synthetic polymeric materials. Peptides possessing strong binding affinities toward polyurethane (PU) were discovered via biopanning of M13 phage peptide library. The apparent binding constant (K(app)) was as high as 2.68 × 10(9) M(-1) with surface peptide density exceeded 1.8 μg/cm(2). Structural analysis showed that the ideal peptide had a high content (75%) of H-donor amino acid residues, and that intensified hydrogen bond interaction was the key driving force for the highly stable binding of peptides on PU. PU treated with such affinity peptides promises applications as low-fouling materials, as peptides increased its wettability and substantially reduced protein adsorption and cell adhesion. These results demonstrated a facile but highly efficient one-step strategy for surface property modification of polymeric materials for biotechnological applications.

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“…The majority of the extracellular part within tissues is filled by proteoglycans consisting of GAG chains, which are linked to a protein core and are classified according to the GAG and core protein arrangement [45]. These proteoglycans have numerous different purposes that mirror their hydration, binding, buffering and force-resistance properties [42,48].…”

Section: Extracellular Matrixmentioning

confidence: 99%

Pluripotent Stem Cells and Their Dynamic Niche

Reinwald¹,

Bratt²,

Haj³

2016

Pluripotent Stem Cells - From the Bench to the Clinic

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Cell-seeded implants are a regenerative medicine strategy that aims to replace injured tissue and restore tissue function. Pluripotent stem cells are promising cell candidates for the development of regenerative medicine therapies as they have the ability to selfrenew and commit towards numerous cell types. In vivo, stem cells reside in a dynamic niche, a stem cell-specific microenvironment that possesses chemical, biological and mechanical cues, which drive the stem cell fate and renewal. The connection between stem cells and their niche is a two-way relationship consisting of both cell-cell interaction and cell-extracellular matrix (ECM) interactions. An alternative regenerative medicine approach is the manipulation of the stem cell microenvironment. Hence, novel strategies have been developed including 3D biomaterials and bioreactor technologies providing topographical, chemical and mechanical cues to recreate the stem cell niche. Understanding the mechanisms controlling stem cell fate and the dynamic nature of the stem cell niche will enable researchers to replicate this stem cell-specific microenvironment, and therefore, harness and control the valuable attributes which stem cells possess. This chapter elucidates the importance of pluripotent stem cells and their dynamic niche in regenerative medicine. It further presents novel strategies to replicate chemical, topographical and mechanical stimuli which are essential for the regulation of stem cell fate and hence tissue regeneration.

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Development of 3D in Vitro Technology for Medical Applications

Cited by 88 publications

References 73 publications

Tailoring chitosan/collagen scaffolds for tissue engineering: Effect of composition and different crosslinking agents on scaffold properties

Tailoring chitosan/collagen scaffolds for tissue engineering: Effect of composition and different crosslinking agents on scaffold properties

One-step surface modification of polyurethane using affinity binding peptides for enhanced fouling resistance

Pluripotent Stem Cells and Their Dynamic Niche

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