Development of 3D printable conductive hydrogel with crystallized PEDOT:PSS for neural tissue engineering

Heo, Dong Nyoung; Lee, Se‐Jun; Timsina, Raju; Qiu, Xiangyun; Castro, Nathan J.

doi:10.1016/j.msec.2019.02.008

Cited by 207 publications

(192 citation statements)

References 40 publications

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“…For example, recent developments of 3D printable materials such as metals 19,20 , liquid metals 21 , hydrogels 22,23 , cellladen bioinks [24][25][26] , glass 27 , liquid crystal polymers 28 , and ferromagnetic elastomers 29 have greatly expanded the accessible materials library for 3D printing. While intensive efforts have been devoted to 3D printing of conducting polymers, only simple structures such as isolated fibers have been achieved [30][31][32] owing to insufficient 3D printability of existing conducting polymer inks.…”

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3D printing of conducting polymers

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Conducting polymers are promising material candidates in diverse applications including energy storage, flexible electronics, and bioelectronics. However, the fabrication of conducting polymers has mostly relied on conventional approaches such as ink-jet printing, screen printing, and electron-beam lithography, whose limitations have hampered rapid innovations and broad applications of conducting polymers. Here we introduce a highperformance 3D printable conducting polymer ink based on poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) for 3D printing of conducting polymers. The resultant superior printability enables facile fabrication of conducting polymers into high resolution and high aspect ratio microstructures, which can be integrated with other materials such as insulating elastomers via multi-material 3D printing. The 3D-printed conducting polymers can also be converted into highly conductive and soft hydrogel microstructures. We further demonstrate fast and streamlined fabrications of various conducting polymer devices, such as a soft neural probe capable of in vivo single-unit recording.

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3D printing of conducting polymers

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“…Depending on the type of functional groups attached to the polymer backbone, the possible reactions used for hydrogel formation or biomolecule coupling involve active esters, anhydrides, isocyanates, epoxides, Michael addition reactions, cross-coupling moieties and click chemistry reactions ( Figure 3 ) [ 52 , 101 , 124 , 126 , 127 , 128 ]. Besides, the functional side groups can also form physical cross-links by hydrogen bonding as in the case of ureidopyrimidone [ 129 ] or polyphenol-based patterns and crystallization [ 130 ]. Other approaches to prepare hydrogels involve host-guest supramolecular interactions, where one polymeric chain is generally decorated with the host molecule and another one with the guest(s).…”

Section: Synthetic Criteria For Hydrogel Productionmentioning

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Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

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Bio-conjugated hydrogels merge the functionality of a synthetic network with the activity of a biomolecule, becoming thus an interesting class of materials for a variety of biomedical applications. This combination allows the fine tuning of their functionality and activity, whilst retaining biocompatibility, responsivity and displaying tunable chemical and mechanical properties. A complex scenario of molecular factors and conditions have to be taken into account to ensure the correct functionality of the bio-hydrogel as a scaffold or a delivery system, including the polymer backbone and biomolecule choice, polymerization conditions, architecture and biocompatibility. In this review, we present these key factors and conditions that have to match together to ensure the correct functionality of the bio-conjugated hydrogel. We then present recent examples of bio-conjugated hydrogel systems paving the way for regenerative medicine applications.

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“…理想的生物材料在具有良好生物相容性的同时, 还应能够促进宿主细胞的增殖、分化, 并改善特定细图 6 (网络版彩色)通过CCK(a)和死/活细胞染色法(b)研究含有PEDOT:PSS的水凝胶表面上背根神经节(DRG)细胞的活性 [74] . 标尺为100 μm, *P<0.05, **P<0.01, n=5 [55,76] .…”

Section: 导电生物材料的多种组织工程应用unclassified

Conductive polymeric biomaterials for tissue regeneration applications

Li¹,

Guo²

2019

Chin. Sci. Bull.

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Development of 3D printable conductive hydrogel with crystallized PEDOT:PSS for neural tissue engineering

Cited by 207 publications

References 40 publications

3D printing of conducting polymers

3D printing of conducting polymers

Design of Bio-Conjugated Hydrogels for Regenerative Medicine Applications: From Polymer Scaffold to Biomolecule Choice

Conductive polymeric biomaterials for tissue regeneration applications

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