Development of 3D-printed subcutaneous implants using concentrated polymer/drug solutions

Picco, Camila J.; Utomo, Emilia; McClean, Anne-Marie; Domínguez-Robles, Juan; Anjani, Qonita Kurnia; Volpe-Zanuto, Fabiana; McKenna, Peter E.; Acheson, Jonathan; Malinova, Dessislava; Donnelly, Ryan F.; Larrañeta, Eneko

doi:10.1016/j.ijpharm.2022.122477

Cited by 24 publications

(6 citation statements)

References 63 publications

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“…These results are thus indicating that the formulation of PLA-PUA/L-PCL-based CLOP-loaded vascular grafts considerably reduced the drug crystallinity, which correlated with improved drug solubility. Similar findings have been reported for different polymeric drug-loaded formulations [ 48 , 58 – 60 ].…”

Section: Resultssupporting

confidence: 90%

Clopidogrel-loaded vascular grafts prepared using digital light processing 3D printing

Adhami,

Picco,

Detamornrat

et al. 2023

Drug Deliv. and Transl. Res.

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The leading cause of death worldwide and a significant factor in decreased quality of life are the cardiovascular diseases. Endovascular operations like angioplasty, stent placement, or atherectomy are often used in vascular surgery to either dilate a narrowed blood artery or remove a blockage. As an alternative, a vascular transplant may be utilised to replace or bypass a dysfunctional or blocked blood vessel. Despite the advancements in endovascular surgery and its popularisation over the past few decades, vascular bypass grafting remains prevalent and is considered the best option for patients in need of long-term revascularisation treatments. Consequently, the demand for synthetic vascular grafts composed of biocompatible materials persists. To address this need, biodegradable clopidogrel (CLOP)-loaded vascular grafts have been fabricated using the digital light processing (DLP) 3D printing technique. A mixture of polylactic acid-polyurethane acrylate (PLA-PUA), low molecular weight polycaprolactone (L-PCL), and CLOP was used to achieve the required mechanical and biological properties for vascular grafts. The 3D printing technology provides precise detail in terms of shape and size, which lead to the fabrication of customised vascular grafts. The fabricated vascular grafts were fully characterised using different techniques, and finally, the drug release was evaluated. Results suggested that the performed 3D-printed small-diameter vascular grafts containing the highest CLOP cargo (20% w/w) were able to provide a sustained drug release for up to 27 days. Furthermore, all the CLOP-loaded 3D-printed materials resulted in a substantial reduction of the platelet deposition across their surface compared to the blank materials containing no drug. Haemolysis percentage for all the 3D-printed samples was lower than 5%. Moreover, 3D-printed materials were able to provide a supportive environment for cellular attachment, viability, and growth. A substantial increase in cell growth was detected between the blank and drug-loaded grafts. Graphical Abstract

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Section: Resultssupporting

confidence: 90%

Clopidogrel-loaded vascular grafts prepared using digital light processing 3D printing

Adhami,

Picco,

Detamornrat

et al. 2023

Drug Deliv. and Transl. Res.

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“…The implants were prepared in a cylindrical shape and included PCL, PEG, and olanzapine (50 and 80 wt%). Drug release analyses demonstrated the accomplishment of a constant drug release profile in all the 3D-printed formulations, with 60% of the maximum drug release occurring within a period of more than 200 days [75].…”

Section: Polyethylene Glycolmentioning

confidence: 91%

“…Recently, Picco et al [75] created subcutaneous implants loaded with a model drug using the robotic material extrusion 3D printing technique. This is a novel extrusion-based printing method in which a robotic device is able to deposit the molten polymer layer by layer with higher precision.…”

Section: Polyethylene Glycolmentioning

confidence: 99%

An Approach to 3D Printing Techniques, Polymer Materials, and Their Applications in the Production of Drug Delivery Systems

Cardoso,

Araújo

2024

Compounds

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Three-dimensional printing (3DP) technologies are characterized as a set of innovative manufacturing techniques that allow for the creation of complex and/or personalized three-dimensional physical objects on the work surface of a 3D printing machine (based on the computer-aided design (CAD) project designs of these parts). Three-dimensional printing techniques are widely used in various areas of knowledge, such as education, engineering, and biomedicine. Polymeric materials are widely used for these applications, mainly due to their desirable workability during part manufacturing, compatibility with other chemical materials, the wide range of polymers with different physical and chemical characteristics, and the possibility for recycling. The development of polymeric drug delivery systems (DDSs) by 3D printing is currently an active field of research, both in academia and industry, given the potential of this technique for medical purposes. In this context, this work reviews potential polymers for the production of drug delivery systems via 3D printing techniques. The demonstrations of the main 3DP techniques used for drug delivery applications include their working principles and advantages and how the technologies develop the final product. In addition, potential synthetic and natural polymers that are currently used in 3DP drug delivery devices are presented and discussed based on recent scientific studies.

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“…In design and size this implant is similar to those described in prior research and to products available on the market. [70][71][72] In the selection of polymers for implant formulation, PCL was chosen due to its biocompatible and biodegradable attributes. Notably, this polymer has been previously utilised in the preparation of long-acting implants for drug administration, 70,[73][74][75][76] rendering it a suitable choice for this formulation.…”

Section: Preparation Of the Implant Devicementioning

confidence: 99%

An isocratic RP-HPLC-UV method for simultaneous quantification of tizanidine and lidocaine: application to in vitro release studies of a subcutaneous implant

Picco,

Anjani,

Donnelly

et al. 2024

Anal. Methods

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Development of 3D-printed subcutaneous implants using concentrated polymer/drug solutions

Cited by 24 publications

References 63 publications

Clopidogrel-loaded vascular grafts prepared using digital light processing 3D printing

Clopidogrel-loaded vascular grafts prepared using digital light processing 3D printing

An Approach to 3D Printing Techniques, Polymer Materials, and Their Applications in the Production of Drug Delivery Systems

An isocratic RP-HPLC-UV method for simultaneous quantification of tizanidine and lidocaine: application to in vitro release studies of a subcutaneous implant

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