Development of 68Ga ethyl cysteinate dimer for PET studies

Mirzaei, Alireza; Jalilian, Amir Reza; Shabani, Gholamali; Fakhari, Ashraf; Akhlaghi, Mehdi; Beiki, Davood

doi:10.1007/s10967-015-4185-3

Cited by 6 publications

(2 citation statements)

References 17 publications

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“…Despite a bifunctional derivative (B6SS, Figure J), to the best of our knowledge no bioconjugated analogue has been published . More recently, thiol-containing ligands, ECC (ethylenecysteamine cysteine; Figure M) and ECD (ethyl cysteinate dimer; Figure M), which are popular with 99m Tc tracers, were shown to be useful for 68 Ga-based renal and cerebral blood flow imaging, respectively. , A number of polyaminopolyphenol Schiff base complexes have demonstrated the ability to form stable complexes with Ga 3+ and radiolabeled 67/68 Ga for use in myocardial imaging, , P-glycoprotein mediated transport imaging, and most recently as metalloprobes for rat cardiomyoblasts and human breast carcinoma cells …”

Section: Galliummentioning

confidence: 99%

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

2018

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Radiometals possess an exceptional breadth of decay properties and have been applied to medicine with great success for several decades. The majority of current clinical use involves diagnostic procedures, which use either positron-emission tomography (PET) or single-photon imaging to detect anatomic abnormalities that are difficult to visualize using conventional imaging techniques (e.g., MRI and X-ray). The potential of therapeutic radiometals has more recently been realized and relies on ionizing radiation to induce irreversible DNA damage, resulting in cell death. In both cases, radiopharmaceutical development has been largely geared toward the field of oncology; thus, selective tumor targeting is often essential for efficacious drug use. To this end, the rational design of fourcomponent radiopharmaceuticals has become popularized. This Review introduces fundamental concepts of drug design and applications, with particular emphasis on bifunctional chelators (BFCs), which ensure secure consolidation of the radiometal and targeting vector and are integral for optimal drug performance. Also presented are detailed accounts of production, chelation chemistry, and biological use of selected main group and rare earth radiometals.

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Section: Galliummentioning

confidence: 99%

Radioactive Main Group and Rare Earth Metals for Imaging and Therapy

2018

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“…The imaging protocol was the same with already reported trend [16]. PET/CT imaging was performed with a PET/CT scanner (Biograph 6 TrueX; Siemens Medical Solutions).The rats were placed in a supine position.…”

Section: Imaging Studiesmentioning

confidence: 99%