2009
DOI: 10.1016/j.rmed.2008.10.010
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Development of a 1-concentration-4-step dosimeter protocol for methacholine testing

Abstract: Methacholine testing is an important diagnostic tool for asthma. Newly available dosimeter and software technology allows for simplification of the test. This study aimed to evaluate a single-concentration dosimeter protocol for methacholine testing by comparison with a multi-concentration dosimeter protocol similar to that recommended by the American Thoracic Society (ATS) (standard protocol). Fifty young subjects with high pretest probability for bronchial hyperresponsiveness underwent two challenges in rand… Show more

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Cited by 39 publications
(26 citation statements)
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“…However, in contrast to a previously proposed 4-step procedure [39], a one-concentration-3-step protocol with increasing single doses of MCH (0.2 mg, 0.8 mg, 1.2 mg) was performed, consisting of 3 consecutive levels of cumulative doses defined as CD 1 : 0.2 mg; CD 2 : 1.0 mg; CD 3 : 2.2 mg. The measurements of whole-body plethysmography and spirometry were performed two minutes after each MCH-inhalation.…”
Section: Methodsmentioning
confidence: 93%
See 1 more Smart Citation
“…However, in contrast to a previously proposed 4-step procedure [39], a one-concentration-3-step protocol with increasing single doses of MCH (0.2 mg, 0.8 mg, 1.2 mg) was performed, consisting of 3 consecutive levels of cumulative doses defined as CD 1 : 0.2 mg; CD 2 : 1.0 mg; CD 3 : 2.2 mg. The measurements of whole-body plethysmography and spirometry were performed two minutes after each MCH-inhalation.…”
Section: Methodsmentioning
confidence: 93%
“…MCT was performed according to a protocol routinely used in several pulmonary function laboratories in Europe, applying a modified dose oriented, single concentration sequence [39] with the Aerosol Provocation System (APS) using the SideStream nebulizer of Philips/Respironics previously described [38, 40]. Technical details and advantages of the APS are given in the Additional file 2, presenting the similar physical characteristics likewise they were recently outlined by Kannan et al [41].…”
Section: Methodsmentioning
confidence: 99%
“…These subjects were given a series consisting of one, three, and six breaths at a dose of 2 mg, followed by three and six breaths at a dose of 32 mg. Methacholine was administered by an electronic, softwarecontrolled (automatic) APSpro dosimeter (Viasys Healthcare) designed to deliver doses equivalent to those given using the original method. This protocol has previously been described in the literature (26).…”
Section: Bronchoprovocation Testingmentioning
confidence: 99%
“…Reference values from the European Coal and Steel Community were used (Quanjer et al 1993). Methacholine testing was performed using the 5-step dosimeter method recently described by the ATS, with minor modiWcations (American Thoracic Society 2000; Merget et al 2009). Bronchial hyperresponsiveness was assumed in this study if a fall of forced expiratory volume in one second (FEV 1 ) of at least 20% occurred after the forth step or earlier.…”
Section: Spirometry and Methacholine Testingmentioning
confidence: 99%