Development of a 15-gene signature for predicting prognosis in advanced colorectal cancer

Abstract

Advanced colorectal cancer (CRC) is a significant cause of cancer mortality, with a poor prognosis. Here, we identified a novel prognostic signature for predicting survival of advanced CRC. Advanced CRC data were used (training set: n = 267 and validation set: n = 264). The survival analyses were investigated. The functional analysis of the prognostic signature was examined. In this study, our 15-gene signature was established and was an independent prognostic factor of advanced CRC. Stratification analyses also showed that this signature was still powerful for survival prediction in each stratum of age, gender, stage, and metastasis status. In mechanism, our signature involved in DNA replication, DNA damage, and cell cycle. Therefore, our findings suggested that this 15-gene signature has prognostic and predictive value in advanced CRC, which could be further used in personalized therapy for advanced CRC. ARTICLE HISTORY

Prognostic and immunological roles of Fc fragment of IgG binding protein in colorectal cancer

“…Due to the relatively high percentage of patients with CRC and distant metastasis at the time of initial diagnosis ( 3 ), identification of novel and effective biomarkers for early diagnosis may contribute to the improvement of early screening for CRC. Omics technologies provide powerful methods to identify potential biomarkers for early diagnosis ( 53 ).…”

“…In China, CRC is the fifth leading cause of death, with continuing increases in incidence (12.2%) and mortality (8.6%) ( 2 ). In addition, ~20% of patients with CRC present with distant metastases at the time of initial diagnosis ( 3 ). Despite notable advances in treatment strategies for CRC, such as surgery, chemotherapy and radiotherapy, >50% of patients with CRC develop metastasis, leading to a high mortality rate ( 4 , 5 ).…”

Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G1/S cell cycle arrest in human colorectal cancer cells via ROS generation

“…It is associated with obesity, type 2 diabetes and chronic inflammatory disease ( 2 ). Although progress has been achieved in the traditional treatment of CRC, it remains one of the most lethal malignancies globally due to the limited therapeutics, high recurrence rate and poor prognosis ( 3 ). Thus, identification of safer and more effective treatments for CRC is required.…”

ORMDL1 is Upregulated and Associated With Favorable Outcome in Colorectal Cancer

“…Although new treatment strategies for CRC besides surgical resection, e. g., radiotherapy, chemotherapy, immunotherapy or targeted therapy have been developed, about 50% of CRC patients who developed metastasis still exhibited poor survival rate (5)(6)(7). Some biomarkers had been found to achieve early prognosis as well as for targeted therapy and molecular strati cation in CRC (8,9).Similarly, to nd more promising biomarkers for the detection and diagnosis of early metastases of CRC is an valuable and advantageous approach to improve patients's survival.…”