Progress and development in the overall industrial sector have been revolutionized by the advent of advanced digital tools and technologies, transitioning towards Industry 5.0 (I5.0), and the term Construction 5.0 (C5.0) is derived from the emergence of I5.0 in Europe. Given its currency, C5.0 remains a nascent and under-explored research area. This review article presents a bibliometric analysis of studies on C5.0, identifying and analyzing challenges and opportunities in its adoption and exploring the strategies to overcome such challenges and ways to maximize productivity from potential opportunities. Fifty-seven relevant documents were studied to accomplish the aim of this study, which were identified from the Scopus database, evaluated, and included based on the PRISMA framework. The findings showed a relatively small but growing body of literature on C5.0 research, which is disseminated globally and grouped into four specific objective categories. This pattern suggests a growing recognition of C5.0’s potential in the construction field, reflecting its expanding influence in the scientific community. Furthermore, the study examined seven critical challenges, including insufficient technological maturity, the absence of standardization, privacy concerns, ethical considerations, and more. It also explores four potential opportunities associated with the adoption of the C5.0 vision, emphasizing its alignment with societal objectives, sustainability initiatives, personalization, and profitability.