Development of a bioadhesive nanoformulation with<i>Glycyrrhiza glabra</i>L. extract against<i>Candida albicans</i>

Roque, Luís; Duarte, Noélia; Bronze, Maria Rosário; García, Catarina; Alopaeus, Julia Fredrika; Molpeceres, Jesús; Hagesæther, Ellen; Tho, Ingunn; Rijo, Patrícia; Reis, Catarina Pinto

doi:10.1080/08927014.2018.1514391

Cited by 19 publications

(11 citation statements)

References 40 publications

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“…These mucoadhesive nanoparticles enhance the absorption of G. glabra L. extract on oral mucosa. Roque et al (2018) Liposomes of Glycyrrhiza glabra L. (inhalable)…”

Section: Discussionmentioning

confidence: 99%

Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation

Stan

Enciu

Mateescu³

et al. 2021

Front. Pharmacol.

123

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Due to the increasing prevalence of life-threatening bacterial, fungal and viral infections and the ability of these human pathogens to develop resistance to current treatment strategies, there is a great need to find and develop new compunds to combat them. These molecules must have low toxicity, specific activity and high bioavailability. The most suitable compounds for this task are usually derived from natural sources (animal, plant or even microbial). In this review article, the latest and most promising natural compounds used to combat bacteria, filamentous fungi and viruses are presented and evaluated. These include plant extracts, essential oils, small antimicrobial peptides of animal origin, bacteriocins and various groups of plant compounds (triterpenoids; alkaloids; phenols; flavonoids) with antimicrobial and antiviral activity. Data are presented on the inhibitory activity of each natural antimicrobial substance and on the putative mechanism of action against bacterial and fungal strains. The results show that among the bioactive compounds studied, triterpenoids have significant inhibitory activity against coronaviruses, but flavonoids have also been shown to inhibit SARS-COV-2. The last chapter is devoted to nanocarriers used to improve stability, bioavailability, cellular uptake/internalization, pharmacokinetic profile and reduce toxicity of natural compunds. There are a number of nanocarriers such as liposomes, drug delivery microemulsion systems, nanocapsules, solid lipid nanoparticles, polymeric micelles, dendrimers, etc. However, some of the recent studies have focused on the incorporation of natural substances with antimicrobial/antiviral activity into polymeric nanoparticles, niosomes and silver nanoparticles (which have been shown to have intrinsic antimicrobial activity). The natural antimicrobials isolated from animals and microorganisms have been shown to have good inhibitory effect on a range of pathogens, however the plants remain the most prolific source. Even if the majority of the studies for the biological activity evaluation are in silico or in vitro, their internalization in the optimum nanocarriers represents the future of “green therapeutics” as shown by some of the recent work in the field.

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“…These mucoadhesive nanoparticles enhance the absorption of G. glabra L. extract on oral mucosa. Roque et al (2018) Liposomes of Glycyrrhiza glabra L. (inhalable)…”

Section: Discussionmentioning

confidence: 99%

Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation

Stan

Enciu

Mateescu³

et al. 2021

Front. Pharmacol.

123

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“…The above experimental results show that the targeted nanoparticles targeted R. solanacearum. contents, and its antibacterial ability has been proven [31]. Figure 6E shows the electrophoretic results of E. coli and R. solanacearum treated with targeted nanoparticles and cultured under regular conditions.…”

Section: Test Results Of Targeting Ability Of Plga-tnpsmentioning

confidence: 99%

“…Meanwhile, few targeted nanoparticles were visible on the cell surface of R. solanacearum. Therefore, compared to ordinary nanoparticles, targeted nanoparticles may more easily bind specifically to R. solanacearum and destroy the surface structure of the bacterial membrane, resulting in an overflow of R. solanacearum cell contents, and its antibacterial ability has been proven [31]. Figure 6E shows the electrophoretic results of E. coli and R. solanacearum treated with targeted nanoparticles and cultured under regular conditions.…”

Section: Test Results Of Targeting Ability Of Plga-tnpsmentioning

confidence: 99%

Novel Poly-(Lactic-Co-Glycolic Acid) Targeted Nanoparticles Conjunct with Antibody for the Enhancement of Antibacterial Activity against Ralstonia solanacearum

Yang

Geng

et al. 2021

Agronomy

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Due to the strong pathogenicity of Ralstonia solanacearum, a variety of strategies have been used to develop antibacterial agents; however, antibacterial drugs with targeted effects on R. solanacearum remain lacking. Herein, we present a nanoagent targeting R. solanacearum based on our previous research on poly-(lactic-co-glycolic acid) (PLGA) particles (PLGA-NPs) loaded with methyl caffeate and caffeic acid phenethyl ester. Antibodies that have specific effects on R. solanacearum, which were verified using immuno-PCR, were first used to prepare PLGA-targeted nanoparticles (PLGA-TNPs). The antibody coupling process was investigated in terms of antibody binding degree and antibacterial activity. The EC50 value of PLGA-TNPs was 0.021 mg/mL, which was significantly reduced by 92% in comparison to PLGA-NPs. PLGA-TNPs had a perforating effect on the cell membrane of R. solanacearum, but no effects on Escherichia coli according to the SEM results. In addition, a downregulation of the pathogenicity-related genes compared to PLGA-NP treatment was observed, and the expression of egl, phcA, phcB, pilT, polA-238, and pehC decreased by 78, 79, 87, 61, 58, and 41%, respectively. Therefore, PLGA-targeted nanoparticles not only enhance the activity against R. solanacearum, but also provide a new idea for controlling bacterial wilt.

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“…Mucoadhesives, gels, toothpastes, buccal tablets, and buccal films have been proposed as treatments for oral candidiasis. Such formulations were developed with NPs for improved local delivery of drugs like miconazole [176,[188][189][190], nystatin [173,177], amphotericin B [191], and fluconazole [192], or plant-derived products, such as stigmasterol [193] or Glycyrrhiza glabra L. extract [194]. Some of these formulations presented enhanced antifungal activity, reduced cytotoxicity, faster drug release rate, improved dissolution rate, and better prolonged release than marketed products or the non-loaded drug [176,[188][189][190][191], while others, despite not being compared to commercialized products, have shown promising results [173,177,[192][193][194].…”

Section: Oral Candidiasis and Denture Stomatitismentioning

confidence: 99%

Nanoparticles in Dentistry: A Comprehensive Review

2021

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In recent years, nanoparticles (NPs) have been receiving more attention in dentistry. Their advantageous physicochemical and biological properties can improve the diagnosis, prevention, and treatment of numerous oral diseases, including dental caries, periodontal diseases, pulp and periapical lesions, oral candidiasis, denture stomatitis, hyposalivation, and head, neck, and oral cancer. NPs can also enhance the mechanical and microbiological properties of dental prostheses and implants and can be used to improve drug delivery through the oral mucosa. This paper reviewed studies from 2015 to 2020 and summarized the potential applications of different types of NPs in the many fields of dentistry.

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Development of a bioadhesive nanoformulation withGlycyrrhiza glabraL. extract againstCandida albicans

Cited by 19 publications

References 40 publications

Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation

Natural Compounds With Antimicrobial and Antiviral Effect and Nanocarriers Used for Their Transportation

Novel Poly-(Lactic-Co-Glycolic Acid) Targeted Nanoparticles Conjunct with Antibody for the Enhancement of Antibacterial Activity against Ralstonia solanacearum

Nanoparticles in Dentistry: A Comprehensive Review

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