Development of a Bioimpedance Measuring Plate for the Study of Hypoxic and Hyperoxic Conditions in Cell Cultures

Filotas, Nora; Helt, Reka; Hencz, Alexandra Júlia; Tenzlinger, Kristof; Odry, Ákos; Ódry, Péter; Karádi, Zoltán; Vizvári, Zoltán; Tóth, Attila; Gyorfi, Nina; Széchenyi, Aleksandar; Pál, József

doi:10.1109/saci51354.2021.9465616

Cited by 2 publications

(1 citation statement)

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“…al showed that varying electrode separation distances between 1 and 5 mm did not result in a significant change in uncompensated resistances. 45 Since the e-bandage itself has a ∼3.36 mm thickness, R u was not included in the simulation. The model results showed that the variation was 10 −4 V which is small due to the high salinity of the electrolyte.…”

Section: During the Initial Estimation Of Electrochemical Parameters ...mentioning

confidence: 99%

Electrochemical H₂O₂ Production Modelling for an Electrochemical Bandage

Ozdemir,

Picioreanu,

Patel

et al. 2024

J. Electrochem. Soc.

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Hydrogen peroxide (H2O2) is an environmentally friendly oxidizing agent used to treat wound infections. We have developed an electrochemical bandage (e-bandage), which in situ generates H2O2 and shows in vitro and in vivo efficacy. The electrochemical bandage comprises carbon fabric working and counter electrodes, as well as an Ag/AgCl quasi-reference electrode, separated by cotton fabric and the electrolyte is made of Xanthan gum with phosphate buffer saline. While the chemistry and electrochemistry of the e-bandage have been experimentally characterized, the system level description could aid in better designing these devices. Here, a model called electrochemical hydrogen peroxide production (EHPP) was used to evaluate factors influencing the electrochemical generation of H2O2, including electrode potentials, diffusion and reaction rates, temperature, and various geometries. Several EHPP model parameters were estimated based on experimental results which indicate that: i) with diffusion limitations caused by changes in physical conditions (e.g., drying of hydrogel) the rate of H2O2 generation decreases, ii) higher working electrode overpotentials increases the H2O2 generation and higher counter electrode overpotentials does not affect the H2O2 generation iii) increasing the distance between electrodes by adding more hydrogel reduces H2O2 generation, iv) net H2O2 generation decreases ~12% with temperature, and v) H2O2 production is most effective within the initial 48 hours of operation

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Section: During the Initial Estimation Of Electrochemical Parameters ...mentioning

confidence: 99%